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Trends in the Association of Parental History of Obesity over 60 Years

OBJECTIVE: The association of familial as compared to genetic factors in the current obesogenic environment, compared to earlier, leaner time periods, is uncertain. DESIGN AND METHODS: Participants from the Framingham Heart Study were classified according to parental obesity status in the Original,...

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Autores principales: Fox, Caroline S., Pencina, Michael J., Heard-Costa, Nancy L., Shrader, Peter, Jaquish, Cashell, O’Donnell, Christopher J., Vasan, Ramachandran S., Cupples, L. Adrienne, D’Agostino, Ralph B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887126/
https://www.ncbi.nlm.nih.gov/pubmed/23836774
http://dx.doi.org/10.1002/oby.20564
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author Fox, Caroline S.
Pencina, Michael J.
Heard-Costa, Nancy L.
Shrader, Peter
Jaquish, Cashell
O’Donnell, Christopher J.
Vasan, Ramachandran S.
Cupples, L. Adrienne
D’Agostino, Ralph B.
author_facet Fox, Caroline S.
Pencina, Michael J.
Heard-Costa, Nancy L.
Shrader, Peter
Jaquish, Cashell
O’Donnell, Christopher J.
Vasan, Ramachandran S.
Cupples, L. Adrienne
D’Agostino, Ralph B.
author_sort Fox, Caroline S.
collection PubMed
description OBJECTIVE: The association of familial as compared to genetic factors in the current obesogenic environment, compared to earlier, leaner time periods, is uncertain. DESIGN AND METHODS: Participants from the Framingham Heart Study were classified according to parental obesity status in the Original, Offspring, and Third Generation cohorts; mean BMI levels were estimated and we compared the association of parental history across generations. Finally, a genetic risk score comprised of 32 well-replicated single nucleotide polymorphisms for BMI was examined in association with BMI levels in 1948, 1971, and 2002. RESULTS: BMI was 1.49 kg/m(2) higher per each affected parent among the Offspring, and increased to 2.09 kg/m(2) higher among the Third Generation participants (p-value for the cohort comparison=0.007). Parental history of obesity was associated with increased weight gain (p<0.0001) and incident obesity (p=0.009). Despite a stronger association of parental obesity with offspring BMI in more contemporary time periods, we observed no change in the effect size of a BMI genetic risk score from 1948 to 2002 (p=0.11 for test of trend across the time periods). CONCLUSIONS: The association of parental obesity has become stronger in more contemporary time period, whereas the association of a BMI genetic risk score has not changed.
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spelling pubmed-38871262014-09-01 Trends in the Association of Parental History of Obesity over 60 Years Fox, Caroline S. Pencina, Michael J. Heard-Costa, Nancy L. Shrader, Peter Jaquish, Cashell O’Donnell, Christopher J. Vasan, Ramachandran S. Cupples, L. Adrienne D’Agostino, Ralph B. Obesity (Silver Spring) Article OBJECTIVE: The association of familial as compared to genetic factors in the current obesogenic environment, compared to earlier, leaner time periods, is uncertain. DESIGN AND METHODS: Participants from the Framingham Heart Study were classified according to parental obesity status in the Original, Offspring, and Third Generation cohorts; mean BMI levels were estimated and we compared the association of parental history across generations. Finally, a genetic risk score comprised of 32 well-replicated single nucleotide polymorphisms for BMI was examined in association with BMI levels in 1948, 1971, and 2002. RESULTS: BMI was 1.49 kg/m(2) higher per each affected parent among the Offspring, and increased to 2.09 kg/m(2) higher among the Third Generation participants (p-value for the cohort comparison=0.007). Parental history of obesity was associated with increased weight gain (p<0.0001) and incident obesity (p=0.009). Despite a stronger association of parental obesity with offspring BMI in more contemporary time periods, we observed no change in the effect size of a BMI genetic risk score from 1948 to 2002 (p=0.11 for test of trend across the time periods). CONCLUSIONS: The association of parental obesity has become stronger in more contemporary time period, whereas the association of a BMI genetic risk score has not changed. 2014-02-06 2014-03 /pmc/articles/PMC3887126/ /pubmed/23836774 http://dx.doi.org/10.1002/oby.20564 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Fox, Caroline S.
Pencina, Michael J.
Heard-Costa, Nancy L.
Shrader, Peter
Jaquish, Cashell
O’Donnell, Christopher J.
Vasan, Ramachandran S.
Cupples, L. Adrienne
D’Agostino, Ralph B.
Trends in the Association of Parental History of Obesity over 60 Years
title Trends in the Association of Parental History of Obesity over 60 Years
title_full Trends in the Association of Parental History of Obesity over 60 Years
title_fullStr Trends in the Association of Parental History of Obesity over 60 Years
title_full_unstemmed Trends in the Association of Parental History of Obesity over 60 Years
title_short Trends in the Association of Parental History of Obesity over 60 Years
title_sort trends in the association of parental history of obesity over 60 years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887126/
https://www.ncbi.nlm.nih.gov/pubmed/23836774
http://dx.doi.org/10.1002/oby.20564
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