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Trends in the Association of Parental History of Obesity over 60 Years
OBJECTIVE: The association of familial as compared to genetic factors in the current obesogenic environment, compared to earlier, leaner time periods, is uncertain. DESIGN AND METHODS: Participants from the Framingham Heart Study were classified according to parental obesity status in the Original,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887126/ https://www.ncbi.nlm.nih.gov/pubmed/23836774 http://dx.doi.org/10.1002/oby.20564 |
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author | Fox, Caroline S. Pencina, Michael J. Heard-Costa, Nancy L. Shrader, Peter Jaquish, Cashell O’Donnell, Christopher J. Vasan, Ramachandran S. Cupples, L. Adrienne D’Agostino, Ralph B. |
author_facet | Fox, Caroline S. Pencina, Michael J. Heard-Costa, Nancy L. Shrader, Peter Jaquish, Cashell O’Donnell, Christopher J. Vasan, Ramachandran S. Cupples, L. Adrienne D’Agostino, Ralph B. |
author_sort | Fox, Caroline S. |
collection | PubMed |
description | OBJECTIVE: The association of familial as compared to genetic factors in the current obesogenic environment, compared to earlier, leaner time periods, is uncertain. DESIGN AND METHODS: Participants from the Framingham Heart Study were classified according to parental obesity status in the Original, Offspring, and Third Generation cohorts; mean BMI levels were estimated and we compared the association of parental history across generations. Finally, a genetic risk score comprised of 32 well-replicated single nucleotide polymorphisms for BMI was examined in association with BMI levels in 1948, 1971, and 2002. RESULTS: BMI was 1.49 kg/m(2) higher per each affected parent among the Offspring, and increased to 2.09 kg/m(2) higher among the Third Generation participants (p-value for the cohort comparison=0.007). Parental history of obesity was associated with increased weight gain (p<0.0001) and incident obesity (p=0.009). Despite a stronger association of parental obesity with offspring BMI in more contemporary time periods, we observed no change in the effect size of a BMI genetic risk score from 1948 to 2002 (p=0.11 for test of trend across the time periods). CONCLUSIONS: The association of parental obesity has become stronger in more contemporary time period, whereas the association of a BMI genetic risk score has not changed. |
format | Online Article Text |
id | pubmed-3887126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-38871262014-09-01 Trends in the Association of Parental History of Obesity over 60 Years Fox, Caroline S. Pencina, Michael J. Heard-Costa, Nancy L. Shrader, Peter Jaquish, Cashell O’Donnell, Christopher J. Vasan, Ramachandran S. Cupples, L. Adrienne D’Agostino, Ralph B. Obesity (Silver Spring) Article OBJECTIVE: The association of familial as compared to genetic factors in the current obesogenic environment, compared to earlier, leaner time periods, is uncertain. DESIGN AND METHODS: Participants from the Framingham Heart Study were classified according to parental obesity status in the Original, Offspring, and Third Generation cohorts; mean BMI levels were estimated and we compared the association of parental history across generations. Finally, a genetic risk score comprised of 32 well-replicated single nucleotide polymorphisms for BMI was examined in association with BMI levels in 1948, 1971, and 2002. RESULTS: BMI was 1.49 kg/m(2) higher per each affected parent among the Offspring, and increased to 2.09 kg/m(2) higher among the Third Generation participants (p-value for the cohort comparison=0.007). Parental history of obesity was associated with increased weight gain (p<0.0001) and incident obesity (p=0.009). Despite a stronger association of parental obesity with offspring BMI in more contemporary time periods, we observed no change in the effect size of a BMI genetic risk score from 1948 to 2002 (p=0.11 for test of trend across the time periods). CONCLUSIONS: The association of parental obesity has become stronger in more contemporary time period, whereas the association of a BMI genetic risk score has not changed. 2014-02-06 2014-03 /pmc/articles/PMC3887126/ /pubmed/23836774 http://dx.doi.org/10.1002/oby.20564 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Fox, Caroline S. Pencina, Michael J. Heard-Costa, Nancy L. Shrader, Peter Jaquish, Cashell O’Donnell, Christopher J. Vasan, Ramachandran S. Cupples, L. Adrienne D’Agostino, Ralph B. Trends in the Association of Parental History of Obesity over 60 Years |
title | Trends in the Association of Parental History of Obesity over 60 Years |
title_full | Trends in the Association of Parental History of Obesity over 60 Years |
title_fullStr | Trends in the Association of Parental History of Obesity over 60 Years |
title_full_unstemmed | Trends in the Association of Parental History of Obesity over 60 Years |
title_short | Trends in the Association of Parental History of Obesity over 60 Years |
title_sort | trends in the association of parental history of obesity over 60 years |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887126/ https://www.ncbi.nlm.nih.gov/pubmed/23836774 http://dx.doi.org/10.1002/oby.20564 |
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