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Renal Histologic Parameters Influencing Postoperative Renal Function in Renal Cell Carcinoma Patients
BACKGROUND: Pre-existing non-neoplastic renal diseases or lesions may influence patient renal function after tumor removal. However, its description is often neglected or omitted in pathologic reports. To determine the incidence and clinical significance of non-neoplastic lesions, we retrospectively...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Pathologists and The Korean Society for Cytopathology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887158/ https://www.ncbi.nlm.nih.gov/pubmed/24421849 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.6.557 |
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author | Koh, Myoung Ju Lim, Beom Jin Choi, Kyu Hun Kim, Yon Hee Jeong, Hyeon Joo |
author_facet | Koh, Myoung Ju Lim, Beom Jin Choi, Kyu Hun Kim, Yon Hee Jeong, Hyeon Joo |
author_sort | Koh, Myoung Ju |
collection | PubMed |
description | BACKGROUND: Pre-existing non-neoplastic renal diseases or lesions may influence patient renal function after tumor removal. However, its description is often neglected or omitted in pathologic reports. To determine the incidence and clinical significance of non-neoplastic lesions, we retrospectively examined renal tissues obtained during 85 radical nephrectomies for renal cell carcinoma. METHODS: One paraffin-embedded tissue block from each case containing a sufficient amount of non-tumorous renal parenchyma was cut and processed with hematoxylin and eosin and periodic acid-Schiff methods. Non-neoplastic lesions of each histological compartment were semi-quantitatively and quantitatively evaluated. RESULTS: Among the various histologic lesions found, tubular atrophy, arterial intimal thickening, and glomerulosclerosis were the most common (94.1%, 91.8%, and 88.2%, respectively). Glomerulosclerosis correlated with estimated glomerular filtration rate at the time of surgery, as well as at 1- and 5-years post-surgery (p=.0071), but tubulointerstitial fibrosis or arterial fibrous intimal thickening did not. Post-hoc analysis revealed that glomerulosclerosis of more than 20% predicted post-operative renal function. However, its significance disappeared when gender and age were considered. CONCLUSIONS: In conclusion, non-neoplastic lesions, especially with regard to glomerulosclerosis percentage, should be described in pathology reports to provide additional information on renal function decline. |
format | Online Article Text |
id | pubmed-3887158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Society of Pathologists and The Korean Society for Cytopathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-38871582014-01-13 Renal Histologic Parameters Influencing Postoperative Renal Function in Renal Cell Carcinoma Patients Koh, Myoung Ju Lim, Beom Jin Choi, Kyu Hun Kim, Yon Hee Jeong, Hyeon Joo Korean J Pathol Original Article BACKGROUND: Pre-existing non-neoplastic renal diseases or lesions may influence patient renal function after tumor removal. However, its description is often neglected or omitted in pathologic reports. To determine the incidence and clinical significance of non-neoplastic lesions, we retrospectively examined renal tissues obtained during 85 radical nephrectomies for renal cell carcinoma. METHODS: One paraffin-embedded tissue block from each case containing a sufficient amount of non-tumorous renal parenchyma was cut and processed with hematoxylin and eosin and periodic acid-Schiff methods. Non-neoplastic lesions of each histological compartment were semi-quantitatively and quantitatively evaluated. RESULTS: Among the various histologic lesions found, tubular atrophy, arterial intimal thickening, and glomerulosclerosis were the most common (94.1%, 91.8%, and 88.2%, respectively). Glomerulosclerosis correlated with estimated glomerular filtration rate at the time of surgery, as well as at 1- and 5-years post-surgery (p=.0071), but tubulointerstitial fibrosis or arterial fibrous intimal thickening did not. Post-hoc analysis revealed that glomerulosclerosis of more than 20% predicted post-operative renal function. However, its significance disappeared when gender and age were considered. CONCLUSIONS: In conclusion, non-neoplastic lesions, especially with regard to glomerulosclerosis percentage, should be described in pathology reports to provide additional information on renal function decline. The Korean Society of Pathologists and The Korean Society for Cytopathology 2013-12 2013-12-24 /pmc/articles/PMC3887158/ /pubmed/24421849 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.6.557 Text en © 2013 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Koh, Myoung Ju Lim, Beom Jin Choi, Kyu Hun Kim, Yon Hee Jeong, Hyeon Joo Renal Histologic Parameters Influencing Postoperative Renal Function in Renal Cell Carcinoma Patients |
title | Renal Histologic Parameters Influencing Postoperative Renal Function in Renal Cell Carcinoma Patients |
title_full | Renal Histologic Parameters Influencing Postoperative Renal Function in Renal Cell Carcinoma Patients |
title_fullStr | Renal Histologic Parameters Influencing Postoperative Renal Function in Renal Cell Carcinoma Patients |
title_full_unstemmed | Renal Histologic Parameters Influencing Postoperative Renal Function in Renal Cell Carcinoma Patients |
title_short | Renal Histologic Parameters Influencing Postoperative Renal Function in Renal Cell Carcinoma Patients |
title_sort | renal histologic parameters influencing postoperative renal function in renal cell carcinoma patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887158/ https://www.ncbi.nlm.nih.gov/pubmed/24421849 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.6.557 |
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