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Diffuse Large B-Cell Lymphoma Arising in Warthin's Tumor: Case Study and Review of the Literature
Warthin's tumor is the second most common type of salivary gland tumor. Microscopically, Warthin's tumor displays a proliferative epithelial component and lymphoid stroma. Carcinomas arising from the epithelial component are well known, but malignant transformations of the lymphoid stroma...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Pathologists and The Korean Society for Cytopathology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887162/ https://www.ncbi.nlm.nih.gov/pubmed/24421853 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.6.579 |
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author | Özkök, Güliz Taşlı, Funda Özsan, Nazan Öztürk, Rafet Postacı, Hakan |
author_facet | Özkök, Güliz Taşlı, Funda Özsan, Nazan Öztürk, Rafet Postacı, Hakan |
author_sort | Özkök, Güliz |
collection | PubMed |
description | Warthin's tumor is the second most common type of salivary gland tumor. Microscopically, Warthin's tumor displays a proliferative epithelial component and lymphoid stroma. Carcinomas arising from the epithelial component are well known, but malignant transformations of the lymphoid stroma are rare. When they do occur, they are most commonly B-cell type non-Hodgkin lymphomas. A 60-year-old male patient underwent surgical resection of a parotid mass. After superficial parotidectomy, microscopic examination indicated that the tumor was of epithelial components with basaloid and oncocytic columns of cells neighboring lymphoid components. In addition to the lymphoid follicles with distinct germinal centers, there were large, bizarre and extremely atypical neoplastic cells seen in the lymphoid component. Large neoplastic cells were diffusely CD20 and CD30 positive. The patient was diagnosed with "Warthin's tumor and diffuse large B-cell lymphoma with expression of CD30." The histopathologic and clinical features are discussed along with a review of the literature. |
format | Online Article Text |
id | pubmed-3887162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Society of Pathologists and The Korean Society for Cytopathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-38871622014-01-13 Diffuse Large B-Cell Lymphoma Arising in Warthin's Tumor: Case Study and Review of the Literature Özkök, Güliz Taşlı, Funda Özsan, Nazan Öztürk, Rafet Postacı, Hakan Korean J Pathol Case Study Warthin's tumor is the second most common type of salivary gland tumor. Microscopically, Warthin's tumor displays a proliferative epithelial component and lymphoid stroma. Carcinomas arising from the epithelial component are well known, but malignant transformations of the lymphoid stroma are rare. When they do occur, they are most commonly B-cell type non-Hodgkin lymphomas. A 60-year-old male patient underwent surgical resection of a parotid mass. After superficial parotidectomy, microscopic examination indicated that the tumor was of epithelial components with basaloid and oncocytic columns of cells neighboring lymphoid components. In addition to the lymphoid follicles with distinct germinal centers, there were large, bizarre and extremely atypical neoplastic cells seen in the lymphoid component. Large neoplastic cells were diffusely CD20 and CD30 positive. The patient was diagnosed with "Warthin's tumor and diffuse large B-cell lymphoma with expression of CD30." The histopathologic and clinical features are discussed along with a review of the literature. The Korean Society of Pathologists and The Korean Society for Cytopathology 2013-12 2013-12-24 /pmc/articles/PMC3887162/ /pubmed/24421853 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.6.579 Text en © 2013 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Study Özkök, Güliz Taşlı, Funda Özsan, Nazan Öztürk, Rafet Postacı, Hakan Diffuse Large B-Cell Lymphoma Arising in Warthin's Tumor: Case Study and Review of the Literature |
title | Diffuse Large B-Cell Lymphoma Arising in Warthin's Tumor: Case Study and Review of the Literature |
title_full | Diffuse Large B-Cell Lymphoma Arising in Warthin's Tumor: Case Study and Review of the Literature |
title_fullStr | Diffuse Large B-Cell Lymphoma Arising in Warthin's Tumor: Case Study and Review of the Literature |
title_full_unstemmed | Diffuse Large B-Cell Lymphoma Arising in Warthin's Tumor: Case Study and Review of the Literature |
title_short | Diffuse Large B-Cell Lymphoma Arising in Warthin's Tumor: Case Study and Review of the Literature |
title_sort | diffuse large b-cell lymphoma arising in warthin's tumor: case study and review of the literature |
topic | Case Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887162/ https://www.ncbi.nlm.nih.gov/pubmed/24421853 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.6.579 |
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