A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation

Mutations in LRRK2, encoding the multifunctional protein leucine-rich repeat kinase 2 (LRRK2), are a common cause of Parkinson disease. LRRK2 has been suggested to influence the cytoskeleton as LRRK2 mutants reduce neurite outgrowth and cause an accumulation of hyperphosphorylated Tau. This might ca...

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Detalles Bibliográficos
Autores principales: Law, Bernard M. H., Spain, Victoria A., Leinster, Veronica H. L., Chia, Ruth, Beilina, Alexandra, Cho, Hyun J., Taymans, Jean-Marc, Urban, Mary K., Sancho, Rosa M., Ramírez, Marian Blanca, Biskup, Saskia, Baekelandt, Veerle, Cai, Huaibin, Cookson, Mark R., Berwick, Daniel C., Harvey, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887213/
https://www.ncbi.nlm.nih.gov/pubmed/24275654
http://dx.doi.org/10.1074/jbc.M113.507913

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