Cargando…

Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology

Understanding the formation and propagation of aggregates of the Alzheimer disease-associated Tau protein in vivo is vital for the development of therapeutics for this devastating disorder. Using our recently developed live-cell aggregation sensor in neuron-like cells, we demonstrate that different...

Descripción completa

Detalles Bibliográficos
Autores principales:	Michel, Claire H., Kumar, Satish, Pinotsi, Dorothea, Tunnacliffe, Alan, St. George-Hyslop, Peter, Mandelkow, Eckhard, Mandelkow, Eva-Maria, Kaminski, Clemens F., Kaminski Schierle, Gabriele S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887218/ https://www.ncbi.nlm.nih.gov/pubmed/24235150 http://dx.doi.org/10.1074/jbc.M113.515445

Ejemplares similares

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies
por: Pickhardt, Marcus, et al.
Publicado: (2015)

Pathogenic tau does not drive activation of the unfolded protein response
por: Pitera, Aleksandra P., et al.
Publicado: (2019)

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner
por: Polanco, Juan Carlos, et al.
Publicado: (2016)

In situ studies of protein aggregation kinetics with multiparametric and superresolution imaging
por: Kaminski Schierle, Gabriele, et al.
Publicado: (2013)

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
por: Tepper, Katharina, et al.
Publicado: (2014)

Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia
por: Lemke, Nora, et al.
Publicado: (2021)

Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein
por: Timm, Thomas, et al.
Publicado: (2008)

Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates
por: Falcon, Benjamin, et al.
Publicado: (2015)

Spreading of Tau Protein Does Not Depend on Aggregation Propensity
por: Rodrigues, Sara, et al.
Publicado: (2023)

Galectin-8–mediated selective autophagy protects against seeded tau aggregation
por: Falcon, Benjamin, et al.
Publicado: (2018)

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment
por: Pir, Ghulam Jeelani, et al.
Publicado: (2018)

Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice
por: Anglada‐Huguet, Marta, et al.
Publicado: (2021)

Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures
por: Katsikoudi, Antigoni, et al.
Publicado: (2020)

Anti-aggregant tau mutant promotes neurogenesis
por: Joseph, Maria, et al.
Publicado: (2017)

What is the evidence that tau pathology spreads through prion-like propagation?
por: Mudher, Amrit, et al.
Publicado: (2017)

Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease
por: Harrington, Charles R., et al.
Publicado: (2015)

Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer’s disease mouse model
por: Green, Claudia, et al.
Publicado: (2019)

Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity
por: Kumar, Satish, et al.
Publicado: (2014)

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
por: Ambadipudi, Susmitha, et al.
Publicado: (2017)

Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates
por: Savastano, Adriana, et al.
Publicado: (2020)

A Label-Free, Quantitative Assay of Amyloid Fibril Growth Based on Intrinsic Fluorescence
por: Pinotsi, Dorothea, et al.
Publicado: (2013)

Synaptic tau: A pathological or physiological phenomenon?
por: Robbins, Miranda, et al.
Publicado: (2021)

Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau
por: Ambadipudi, Susmitha, et al.
Publicado: (2019)

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments
por: Kaniyappan, Senthilvelrajan, et al.
Publicado: (2020)

Extracellular Monomeric Tau Is Internalized by Astrocytes
por: Perea, Juan Ramón, et al.
Publicado: (2019)

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
por: Cabrales Fontela, Yunior, et al.
Publicado: (2017)

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space
por: Perez-Gonzalez, Rocio, et al.
Publicado: (2012)

Novel antibody against low‐n oligomers of tau protein promotes clearance of tau in cells via lysosomes
por: Chandupatla, Ram Reddy, et al.
Publicado: (2020)

Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy
por: Pinotsi, Dorothea, et al.
Publicado: (2013)

Atypical, non-standard functions of the microtubule associated Tau protein
por: Sotiropoulos, Ioannis, et al.
Publicado: (2017)

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
por: Shammas, Sarah L., et al.
Publicado: (2015)

Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein
por: Majewski, Jaroslaw, et al.
Publicado: (2020)

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes: IMPLICATIONS FOR DISEASE SPREADING AND MOTOR NEURON PATHOLOGY IN AMYOTROPHIC LATERAL SCLEROSIS
por: Basso, Manuela, et al.
Publicado: (2013)

Interplay of pathogenic forms of human tau with different autophagic pathways
por: Caballero, Benjamin, et al.
Publicado: (2017)

Overexpression of Tau Protein Inhibits Kinesin-dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease
por: Ebneth, A., et al.
Publicado: (1998)

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation
por: Decker, Jochen Martin, et al.
Publicado: (2015)

The release and trans-synaptic transmission of Tau via exosomes
por: Wang, Yipeng, et al.
Publicado: (2017)

Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model
por: Pir, Ghulam Jeelani, et al.
Publicado: (2016)

Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing
por: Stephens, Amberley D., et al.
Publicado: (2018)

Initiation and modulation of Tau protein phase separation by the drug suramin
por: Prince, Prabhu Rajaiah, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2ucolmmcomkmu722jq92h1p5ca