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Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism
The recent discovery of DNA methylation in the nematode T.spiralis may raise the possibility of using it as a potential model organism for epigenetic studies instead of C. elegans, which is deficient in this important epigenetic modification. In contrast to the free-living nematode C. elegans, T. sp...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887316/ https://www.ncbi.nlm.nih.gov/pubmed/24454291 http://dx.doi.org/10.3389/fphys.2013.00410 |
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author | Gao, Fei Wang, Rui Liu, Mingyuan |
author_facet | Gao, Fei Wang, Rui Liu, Mingyuan |
author_sort | Gao, Fei |
collection | PubMed |
description | The recent discovery of DNA methylation in the nematode T.spiralis may raise the possibility of using it as a potential model organism for epigenetic studies instead of C. elegans, which is deficient in this important epigenetic modification. In contrast to the free-living nematode C. elegans, T. spiralis is a parasitic worm that possesses a complicated life cycle and undergoes a complex developmental regulation of genes. We emphasize that the differential methylomes in the different life-history stages of T. spiralis can provide insight on how DNA methylation is triggered and regulated. In particular, we have demonstrated that DNA methylation is involved in the regulation of its parasitism-related genes. Further computational analyses indicated that the regulatory machinery for DNA methylation can also be found in the T. spiralis genome. By a logical extension of this point, we speculate that comprehensively addressing the epigenetic machinery of T. spiralis may help to understand epigenetics in invertebrates. Furthermore, considering the implication of epigenetics in metazoan parasitism, using T. spiralis as an epigenetic model organism may further contribute to drug development against metazoan parasites. |
format | Online Article Text |
id | pubmed-3887316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38873162014-01-17 Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism Gao, Fei Wang, Rui Liu, Mingyuan Front Physiol Physiology The recent discovery of DNA methylation in the nematode T.spiralis may raise the possibility of using it as a potential model organism for epigenetic studies instead of C. elegans, which is deficient in this important epigenetic modification. In contrast to the free-living nematode C. elegans, T. spiralis is a parasitic worm that possesses a complicated life cycle and undergoes a complex developmental regulation of genes. We emphasize that the differential methylomes in the different life-history stages of T. spiralis can provide insight on how DNA methylation is triggered and regulated. In particular, we have demonstrated that DNA methylation is involved in the regulation of its parasitism-related genes. Further computational analyses indicated that the regulatory machinery for DNA methylation can also be found in the T. spiralis genome. By a logical extension of this point, we speculate that comprehensively addressing the epigenetic machinery of T. spiralis may help to understand epigenetics in invertebrates. Furthermore, considering the implication of epigenetics in metazoan parasitism, using T. spiralis as an epigenetic model organism may further contribute to drug development against metazoan parasites. Frontiers Media S.A. 2014-01-10 /pmc/articles/PMC3887316/ /pubmed/24454291 http://dx.doi.org/10.3389/fphys.2013.00410 Text en Copyright © 2014 Gao, Wang and Liu. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Gao, Fei Wang, Rui Liu, Mingyuan Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism |
title | Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism |
title_full | Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism |
title_fullStr | Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism |
title_full_unstemmed | Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism |
title_short | Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism |
title_sort | trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887316/ https://www.ncbi.nlm.nih.gov/pubmed/24454291 http://dx.doi.org/10.3389/fphys.2013.00410 |
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