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Morphology of melanocytic lesions in situ
Melanoma is a solid tumour with its own specificity from the biological and morphological viewpoint. On one hand, numerous mutations are already known affecting different pathways. They usually concern proliferation rate, apoptosis, cell senescence and cell behaviour. On the other hand, several visu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887378/ https://www.ncbi.nlm.nih.gov/pubmed/24406374 http://dx.doi.org/10.1038/srep03622 |
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author | Balois, Thibaut Amar, Martine Ben |
author_facet | Balois, Thibaut Amar, Martine Ben |
author_sort | Balois, Thibaut |
collection | PubMed |
description | Melanoma is a solid tumour with its own specificity from the biological and morphological viewpoint. On one hand, numerous mutations are already known affecting different pathways. They usually concern proliferation rate, apoptosis, cell senescence and cell behaviour. On the other hand, several visual criteria at the tissue level are used by physicians in order to diagnose skin lesions. Nevertheless, the mechanisms between the changes from the mutations at the cell level to the morphology exhibited at the tissue level are still not fully understood. Using physical tools, we develop a simple model. We demonstrate analytically that it contains the necessary ingredients to understand several specificities of melanoma such as the presence of microstructures inside a skin lesion or the absence of a necrotic core. We also explain the importance of senescence for growth arrest in benign skin lesions. Thanks to numerical simulations, we successfully compare this model to biological data. |
format | Online Article Text |
id | pubmed-3887378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38873782014-01-10 Morphology of melanocytic lesions in situ Balois, Thibaut Amar, Martine Ben Sci Rep Article Melanoma is a solid tumour with its own specificity from the biological and morphological viewpoint. On one hand, numerous mutations are already known affecting different pathways. They usually concern proliferation rate, apoptosis, cell senescence and cell behaviour. On the other hand, several visual criteria at the tissue level are used by physicians in order to diagnose skin lesions. Nevertheless, the mechanisms between the changes from the mutations at the cell level to the morphology exhibited at the tissue level are still not fully understood. Using physical tools, we develop a simple model. We demonstrate analytically that it contains the necessary ingredients to understand several specificities of melanoma such as the presence of microstructures inside a skin lesion or the absence of a necrotic core. We also explain the importance of senescence for growth arrest in benign skin lesions. Thanks to numerical simulations, we successfully compare this model to biological data. Nature Publishing Group 2014-01-10 /pmc/articles/PMC3887378/ /pubmed/24406374 http://dx.doi.org/10.1038/srep03622 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Balois, Thibaut Amar, Martine Ben Morphology of melanocytic lesions in situ |
title | Morphology of melanocytic lesions in situ |
title_full | Morphology of melanocytic lesions in situ |
title_fullStr | Morphology of melanocytic lesions in situ |
title_full_unstemmed | Morphology of melanocytic lesions in situ |
title_short | Morphology of melanocytic lesions in situ |
title_sort | morphology of melanocytic lesions in situ |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887378/ https://www.ncbi.nlm.nih.gov/pubmed/24406374 http://dx.doi.org/10.1038/srep03622 |
work_keys_str_mv | AT baloisthibaut morphologyofmelanocyticlesionsinsitu AT amarmartineben morphologyofmelanocyticlesionsinsitu |