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Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death

Monocyte-derived antigen presenting cells (APC) are central mediators of the innate and adaptive immune response in inflammatory diseases. As such, APC are appropriate targets for therapeutic intervention to ameliorate certain diseases. APC differentiation, activation and functions are regulated by...

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Detalles Bibliográficos
Autores principales:	Tilstra, Jeremy S., Gaddy, Daniel F., Zhao, Jing, Davé, Shaival H., Niedernhofer, Laura J., Plevy, Scott E., Robbins, Paul D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887388/ https://www.ncbi.nlm.nih.gov/pubmed/24406986 http://dx.doi.org/10.1038/srep03631

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