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Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec(®)) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation
OBJECTIVES: The purpose of the present study was to evaluate the efficacy of adding platelet-rich plasma (PRP) to a new highly purified bovine allograft (Laddec(®)) in the bone regeneration of cystic bony defects augmented following cystectomy. MATERIAL AND METHODS: Study sample included 20 patients...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Stilus Optimus
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887574/ https://www.ncbi.nlm.nih.gov/pubmed/24422036 http://dx.doi.org/10.5037/jomr.2012.4303 |
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author | Pappalardo, Sabrina Guarnieri, Renzo |
author_facet | Pappalardo, Sabrina Guarnieri, Renzo |
author_sort | Pappalardo, Sabrina |
collection | PubMed |
description | OBJECTIVES: The purpose of the present study was to evaluate the efficacy of adding platelet-rich plasma (PRP) to a new highly purified bovine allograft (Laddec(®)) in the bone regeneration of cystic bony defects augmented following cystectomy. MATERIAL AND METHODS: Study sample included 20 patients undergoing cystectomy in which the bone defect was filled with PRP and Laddec(®). All patients were examined with periapical radiographs before operation and at follow-up. After 3 months, at re-entry surgery for implant placement, bone core was taken for histological and histomorphometric analysis. RESULTS: The postoperative successive radiographs showed a good regeneration of bone in the height of bony defects with application of PRP to bone graft. By the first postoperative month, about 48% of the defect was filled, which gradually increased in each month and showed about 90% of defect-fill by 6 months. Histological and histomorphometric analysis, showed a significant presence of bone tissue and vessels, with newly formed bone in contact with anorganic bone particles. The mean volume of vital bone was 68 ± 1.6% and the mean percentage of vital bone was 48 ± 2.4%. The mean percentage of inorganic particles in tissues was 20 ± 1.2% of the total volume. All the samples analyzed did not evidence the presence of inflammatory cells. CONCLUSIONS: The results of this study showed how the use of Laddec(®) in association with platelet-rich plasma allows bone regeneration and has a potential for routine clinical use for regeneration of cystic bony defects. |
format | Online Article Text |
id | pubmed-3887574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Stilus Optimus |
record_format | MEDLINE/PubMed |
spelling | pubmed-38875742014-01-13 Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec(®)) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation Pappalardo, Sabrina Guarnieri, Renzo J Oral Maxillofac Res Original Paper OBJECTIVES: The purpose of the present study was to evaluate the efficacy of adding platelet-rich plasma (PRP) to a new highly purified bovine allograft (Laddec(®)) in the bone regeneration of cystic bony defects augmented following cystectomy. MATERIAL AND METHODS: Study sample included 20 patients undergoing cystectomy in which the bone defect was filled with PRP and Laddec(®). All patients were examined with periapical radiographs before operation and at follow-up. After 3 months, at re-entry surgery for implant placement, bone core was taken for histological and histomorphometric analysis. RESULTS: The postoperative successive radiographs showed a good regeneration of bone in the height of bony defects with application of PRP to bone graft. By the first postoperative month, about 48% of the defect was filled, which gradually increased in each month and showed about 90% of defect-fill by 6 months. Histological and histomorphometric analysis, showed a significant presence of bone tissue and vessels, with newly formed bone in contact with anorganic bone particles. The mean volume of vital bone was 68 ± 1.6% and the mean percentage of vital bone was 48 ± 2.4%. The mean percentage of inorganic particles in tissues was 20 ± 1.2% of the total volume. All the samples analyzed did not evidence the presence of inflammatory cells. CONCLUSIONS: The results of this study showed how the use of Laddec(®) in association with platelet-rich plasma allows bone regeneration and has a potential for routine clinical use for regeneration of cystic bony defects. Stilus Optimus 2013-10-01 /pmc/articles/PMC3887574/ /pubmed/24422036 http://dx.doi.org/10.5037/jomr.2012.4303 Text en Copyright © Pappalardo S, Guarnieri R. Published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH (http://www.ejomr.org), 1 October 2013. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article, first published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH, distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work and is properly cited. The copyright, license information and link to the original publication on http://www.ejomr.org must be included. |
spellingShingle | Original Paper Pappalardo, Sabrina Guarnieri, Renzo Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec(®)) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation |
title | Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec(®)) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation |
title_full | Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec(®)) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation |
title_fullStr | Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec(®)) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation |
title_full_unstemmed | Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec(®)) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation |
title_short | Efficacy of Platelet-Rich-Plasma (PRP) and Highly Purified Bovine Xenograft (Laddec(®)) Combination in Bone Regeneration after Cyst Enucleation: Radiological and Histological Evaluation |
title_sort | efficacy of platelet-rich-plasma (prp) and highly purified bovine xenograft (laddec(®)) combination in bone regeneration after cyst enucleation: radiological and histological evaluation |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887574/ https://www.ncbi.nlm.nih.gov/pubmed/24422036 http://dx.doi.org/10.5037/jomr.2012.4303 |
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