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High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-β and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner

Fibroblasts in the tumor microenvironment are a key determinant in cancer progression and may be a promising target for cancer therapy. Insulin-like growth factor binding protein 7 (IGFBP7) is known as a tumor suppressor in colorectal cancer (CRC). The present study investigated the inductive mechan...

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Detalles Bibliográficos
Autores principales:	Rao, Cui, Lin, Shan-Li, Ruan, Wen-Jing, Wen, Huan, Wu, Dan-Ju, Deng, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888407/ https://www.ncbi.nlm.nih.gov/pubmed/24427302 http://dx.doi.org/10.1371/journal.pone.0085340

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