Cargando…

Novel α-MSH analog causes weight loss in obese rats and minipigs and improves insulin sensitivity

Obesity is a major burden to people and to health care systems around the world. The aim of the study was to characterize the effect of a novel selective α-MSH analog on obesity and insulin sensitivity. The subchronic effects of the selective MC4-R peptide agonist MC4-NN1-0182 were investigated in d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fosgerau, Keld, Raun, Kirsten, Nilsson, Cecilia, Dahl, Kirsten, Wulff, Birgitte S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888513/ https://www.ncbi.nlm.nih.gov/pubmed/24204009 http://dx.doi.org/10.1530/JOE-13-0284

Ejemplares similares

Investigation of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of a Long-Acting α-MSH Analog in Healthy Overweight and Obese Subjects
por: Royalty, Jane E, et al.
Publicado: (2014)

α-MSH Stimulates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1 Independently of AMPK
por: Møller, Cathrine Laustrup, et al.
Publicado: (2016)

Preclinical Weight Loss Efficacy of AM833 in Combination With Semaglutide in Rodent Models of Obesity
por: John, Linu M, et al.
Publicado: (2021)

The effect of fatty diacid acylation of human PYY(3-36) on Y(2) receptor potency and half-life in minipigs
por: Østergaard, Søren, et al.
Publicado: (2021)

Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic Response
por: Vasilyeva, Aksana, et al.
Publicado: (2010)

Obstructive sleep apnea in obese minipigs
por: Deng, Meng-Zhao, et al.
Publicado: (2020)

Magnesium stable isotope composition, but not concentration, responds to obesity and early insulin-resistant conditions in minipig
por: le Goff, Samuel, et al.
Publicado: (2022)

Analytic framework for peptidomics applied to large-scale neuropeptide identification
por: Secher, Anna, et al.
Publicado: (2016)

The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW
por: Nøhr, Anne Cathrine, et al.
Publicado: (2017)

Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss
por: Christoffersen, Berit Østergaard, et al.
Publicado: (2022)

Airflow dynamics in obese minipigs with obstructive sleep apnea
por: Liu, Zi-Jun, et al.
Publicado: (2021)

Hypothalamic oxidative stress and inflammation, and peripheral glucose homeostasis in Sprague-Dawley rat offspring exposed to maternal and postnatal chocolate and soft drink
por: Kjaergaard, Marina, et al.
Publicado: (2018)

Chronic Administration of the Glucagon-Like Peptide-1 Analog, Liraglutide, Delays the Onset of Diabetes and Lowers Triglycerides in UCD-T2DM Rats
por: Cummings, Bethany P., et al.
Publicado: (2010)

Immunohistochemical Loss of the DNA Mismatch Repair Proteins MSH2 and MSH6 in Malignant Fibrous Histiocytomas
por: Ericson, Kajsa, et al.
Publicado: (2004)

Melanocortin agonists stimulate lipolysis in human adipose tissue explants but not in adipocytes
por: Møller, Cathrine Laustrup, et al.
Publicado: (2015)

Desacetyl-α-MSH and α-MSH have sex specific interactions with diet to influence mouse gut morphology, metabolites and microbiota
por: Sun, Bo, et al.
Publicado: (2020)

Predictors of weight loss in young adults who are over-weight or obese and have psychosocial problems: a post hoc analysis
por: Lous, Jørgen, et al.
Publicado: (2016)

Long-acting CCK analogue NN9056 lowers food intake and body weight in obese Göttingen Minipigs
por: Christoffersen, Berit Ø., et al.
Publicado: (2019)

Functional and morphological renal changes in a Göttingen Minipig model of obesity-related and diabetic nephropathy
por: Christoffersen, Berit Østergaard, et al.
Publicado: (2023)

Somatic Hypermutation in Muts Homologue (Msh)3-, Msh6-, and Msh3/Msh6-Deficient Mice Reveals a Role for the Msh2–Msh6 Heterodimer in Modulating the Base Substitution Pattern
por: Wiesendanger, Margrit, et al.
Publicado: (2000)

Antimicrobial Properties of α-MSH and Related Synthetic Melanocortins
por: Catania, A., et al.
Publicado: (2006)

0733. Impact of endotoxin challenge on disseminated intravascular coagulation in obese minipigs
por: Duburcq, T, et al.
Publicado: (2014)

Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs
por: Al-Mashhadi, Ahmed Ludvigsen, et al.
Publicado: (2018)

Loss or Somatic Mutations of hMSH2 Occur in Hereditary Nonpolyposis Colorectal Cancers with hMSH2 Germline Mutations
por: Lu, Shi‐Long, et al.
Publicado: (1996)

Prerecognition Diffusion Mechanism of Human DNA Mismatch Repair Proteins along DNA: Msh2-Msh3 versus Msh2-Msh6
por: Pal, Arumay, et al.
Publicado: (2020)

Dynamic changes of fecal microbiota in a weight-change model of Bama minipigs
por: Zeng, Bo, et al.
Publicado: (2023)

Multi-transgenic minipig models exhibiting potential for hepatic insulin resistance and pancreatic apoptosis
por: KONG, SIYUAN, et al.
Publicado: (2016)

NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair
por: Bone, K M, et al.
Publicado: (2015)

Neuropeptide Y and α-MSH Circadian Levels in Two Populations with Low Body Weight: Anorexia Nervosa and Constitutional Thinness
por: Galusca, Bogdan, et al.
Publicado: (2015)

Characterisation of Gut Microbiota in Ossabaw and Göttingen Minipigs as Models of Obesity and Metabolic Syndrome
por: Pedersen, Rebecca, et al.
Publicado: (2013)

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs
por: Renner, Simone, et al.
Publicado: (2018)

Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet‐Induced Obese Minipigs
por: Chmielewski, Alexandra, et al.
Publicado: (2019)

Sleeve Gastrectomy-Induced Weight Loss Increases Insulin Clearance in Obese Mice
por: Soares, Gabriela Moreira, et al.
Publicado: (2023)

First virological and pathological study of Göttingen Minipigs with Dippity Pig Syndrome (DPS)
por: Jhelum, Hina, et al.
Publicado: (2023)

The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues
por: Berthelsen, Martin Fogtmann, et al.
Publicado: (2021)

Effects of α-MSH on ischemia/reperfusion injury in the rat sciatic nerve
por: Turkoglu, Erhan, et al.
Publicado: (2012)

Novel α-MSH Peptide Analogues with Broad Spectrum Antimicrobial Activity
por: Grieco, Paolo, et al.
Publicado: (2013)

Identification of the ceRNA networks in α-MSH-induced melanogenesis of melanocytes
por: Jiang, Ling, et al.
Publicado: (2020)

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis
por: Kirwan, Peter, et al.
Publicado: (2018)

Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs
por: Soucek, Pavel, et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_sk59dmv9oht6ds3367va1iji3a