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Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

The sugar nucleotide UDP-N-acetylglucosamine (UDP-GlcNAc) is an essential metabolite in both prokaryotes and eukaryotes. In fungi, it is the precursor for the synthesis of chitin, an essential component of the fungal cell wall. UDP-N-acetylglucosamine pyrophosphorylase (UAP) is the final enzyme in e...

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Detalles Bibliográficos
Autores principales:	Fang, Wenxia, Du, Ting, Raimi, Olawale G, Hurtado-Guerrero, Ramon, Urbaniak, Michael D, Ibrahim, Adel F M, Ferguson, Michael A J, Jin, Cheng, Aalten, Daan M F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888555/ https://www.ncbi.nlm.nih.gov/pubmed/23750903 http://dx.doi.org/10.1111/mmi.12290

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