Against all odds: anti-IgE for intrinsic asthma?

For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be eff...

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Autores principales: Lommatzsch, Marek, Korn, Stephanie, Buhl, Roland, Virchow, Johann Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Chest Clinic
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888607/
https://www.ncbi.nlm.nih.gov/pubmed/23709757
http://dx.doi.org/10.1136/thoraxjnl-2013-203738
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author Lommatzsch, Marek
Korn, Stephanie
Buhl, Roland
Virchow, Johann Christian
author_facet Lommatzsch, Marek
Korn, Stephanie
Buhl, Roland
Virchow, Johann Christian
author_sort Lommatzsch, Marek
collection PubMed
description For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment.
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spelling pubmed-38886072014-01-14 Against all odds: anti-IgE for intrinsic asthma? Lommatzsch, Marek Korn, Stephanie Buhl, Roland Virchow, Johann Christian Thorax Chest Clinic For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment. BMJ Publishing Group 2014-01 2013-05-24 /pmc/articles/PMC3888607/ /pubmed/23709757 http://dx.doi.org/10.1136/thoraxjnl-2013-203738 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chest Clinic
Lommatzsch, Marek
Korn, Stephanie
Buhl, Roland
Virchow, Johann Christian
Against all odds: anti-IgE for intrinsic asthma?
title Against all odds: anti-IgE for intrinsic asthma?
title_full Against all odds: anti-IgE for intrinsic asthma?
title_fullStr Against all odds: anti-IgE for intrinsic asthma?
title_full_unstemmed Against all odds: anti-IgE for intrinsic asthma?
title_short Against all odds: anti-IgE for intrinsic asthma?
title_sort against all odds: anti-ige for intrinsic asthma?
topic Chest Clinic
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888607/
https://www.ncbi.nlm.nih.gov/pubmed/23709757
http://dx.doi.org/10.1136/thoraxjnl-2013-203738
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