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Methylcobalamin: A Potential Vitamin of Pain Killer

Methylcobalamin (MeCbl), the activated form of vitamin B12, has been used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis. As an auxiliary agent, it exerts neuronal protection by promoting regeneration of injured nerves and a...

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Detalles Bibliográficos
Autores principales: Zhang, Ming, Han, Wenjuan, Hu, Sanjue, Xu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888748/
https://www.ncbi.nlm.nih.gov/pubmed/24455309
http://dx.doi.org/10.1155/2013/424651
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author Zhang, Ming
Han, Wenjuan
Hu, Sanjue
Xu, Hui
author_facet Zhang, Ming
Han, Wenjuan
Hu, Sanjue
Xu, Hui
author_sort Zhang, Ming
collection PubMed
description Methylcobalamin (MeCbl), the activated form of vitamin B12, has been used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis. As an auxiliary agent, it exerts neuronal protection by promoting regeneration of injured nerves and antagonizing glutamate-induced neurotoxicity. Recently several lines of evidence demonstrated that MeCbl may have potential analgesic effects in experimental and clinical studies. For example, MeCbl alleviated pain behaviors in diabetic neuropathy, low back pain and neuralgia. MeCbl improved nerve conduction, promoted the regeneration of injured nerves, and inhibited ectopic spontaneous discharges of injured primary sensory neurons. This review aims to summarize the analgesic effect and mechanisms of MeCbl at the present.
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spelling pubmed-38887482014-01-22 Methylcobalamin: A Potential Vitamin of Pain Killer Zhang, Ming Han, Wenjuan Hu, Sanjue Xu, Hui Neural Plast Review Article Methylcobalamin (MeCbl), the activated form of vitamin B12, has been used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis. As an auxiliary agent, it exerts neuronal protection by promoting regeneration of injured nerves and antagonizing glutamate-induced neurotoxicity. Recently several lines of evidence demonstrated that MeCbl may have potential analgesic effects in experimental and clinical studies. For example, MeCbl alleviated pain behaviors in diabetic neuropathy, low back pain and neuralgia. MeCbl improved nerve conduction, promoted the regeneration of injured nerves, and inhibited ectopic spontaneous discharges of injured primary sensory neurons. This review aims to summarize the analgesic effect and mechanisms of MeCbl at the present. Hindawi Publishing Corporation 2013 2013-12-26 /pmc/articles/PMC3888748/ /pubmed/24455309 http://dx.doi.org/10.1155/2013/424651 Text en Copyright © 2013 Ming Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Ming
Han, Wenjuan
Hu, Sanjue
Xu, Hui
Methylcobalamin: A Potential Vitamin of Pain Killer
title Methylcobalamin: A Potential Vitamin of Pain Killer
title_full Methylcobalamin: A Potential Vitamin of Pain Killer
title_fullStr Methylcobalamin: A Potential Vitamin of Pain Killer
title_full_unstemmed Methylcobalamin: A Potential Vitamin of Pain Killer
title_short Methylcobalamin: A Potential Vitamin of Pain Killer
title_sort methylcobalamin: a potential vitamin of pain killer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888748/
https://www.ncbi.nlm.nih.gov/pubmed/24455309
http://dx.doi.org/10.1155/2013/424651
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