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High prevalence of low bone mass and associated factors in Korean HIV-positive male patients undergoing antiretroviral therapy

INTRODUCTION: Low bone mass is prevalent in HIV-positive patients. However, compared to Western countries, less is known about HIV-associated osteopenia in Asian populations. METHODS: We performed a cross-sectional survey in Seoul National University Hospital from December 2011 to May 2012. We measu...

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Autores principales: Choe, Pyoeng Gyun, Choi, Hyung Jin, Kim, Nak-Hyun, Park, Wan Beom, Song, Kyoung-Ho, Bang, Ji Hwan, Kim, Eu Suk, Park, Sang Won, Kim, Hong Bin, Oh, Myoung-don, Kim, Nam Joong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International AIDS Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888902/
https://www.ncbi.nlm.nih.gov/pubmed/24433984
http://dx.doi.org/10.7448/IAS.17.1.18773
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author Choe, Pyoeng Gyun
Choi, Hyung Jin
Kim, Nak-Hyun
Park, Wan Beom
Song, Kyoung-Ho
Bang, Ji Hwan
Kim, Eu Suk
Park, Sang Won
Kim, Hong Bin
Oh, Myoung-don
Kim, Nam Joong
author_facet Choe, Pyoeng Gyun
Choi, Hyung Jin
Kim, Nak-Hyun
Park, Wan Beom
Song, Kyoung-Ho
Bang, Ji Hwan
Kim, Eu Suk
Park, Sang Won
Kim, Hong Bin
Oh, Myoung-don
Kim, Nam Joong
author_sort Choe, Pyoeng Gyun
collection PubMed
description INTRODUCTION: Low bone mass is prevalent in HIV-positive patients. However, compared to Western countries, less is known about HIV-associated osteopenia in Asian populations. METHODS: We performed a cross-sectional survey in Seoul National University Hospital from December 2011 to May 2012. We measured bone mineral density using central dual energy X-ray absorptiometry, with consent, in male HIV-positive patients, aged 40 years and older. Diagnosis of low bone mass was made using International Society for Clinical Densitometry Z-score criteria in the 40–49 years age group and World Health Organization T-score criteria in the >50-year age group. The data were compared with those of a community-based cohort in Korea. RESULTS: Eighty-four HIV-positive male patients were included in this study. Median age was 49 (interquartile range [IQR], 45–56) years, and median body mass index (BMI) was 22.6 (IQR, 20.9–24.4). Viral suppression was achieved in 75 (89.3%) patients and median duration of antiretroviral therapy was 71 (IQR, 36–120) months. The overall prevalence of low bone mass was 16.7% in the 40–49 years age group and 54.8% in the>50 years age group. Our cohort had significantly lower bone mass at the femur neck and total hip than HIV-negative Koreans in the 40–49 years age group. Low bone mass was significantly associated with low BMI, and a high level of serum carboxy-terminal collagen crosslinks, but was not associated with antiretroviral regimen or duration of antiretroviral therapy. CONCLUSIONS: Low bone mass is prevalent in Korean HIV-positive males undergoing antiretroviral therapy, and may be associated with increased bone resorption.
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spelling pubmed-38889022014-01-13 High prevalence of low bone mass and associated factors in Korean HIV-positive male patients undergoing antiretroviral therapy Choe, Pyoeng Gyun Choi, Hyung Jin Kim, Nak-Hyun Park, Wan Beom Song, Kyoung-Ho Bang, Ji Hwan Kim, Eu Suk Park, Sang Won Kim, Hong Bin Oh, Myoung-don Kim, Nam Joong J Int AIDS Soc Short Report INTRODUCTION: Low bone mass is prevalent in HIV-positive patients. However, compared to Western countries, less is known about HIV-associated osteopenia in Asian populations. METHODS: We performed a cross-sectional survey in Seoul National University Hospital from December 2011 to May 2012. We measured bone mineral density using central dual energy X-ray absorptiometry, with consent, in male HIV-positive patients, aged 40 years and older. Diagnosis of low bone mass was made using International Society for Clinical Densitometry Z-score criteria in the 40–49 years age group and World Health Organization T-score criteria in the >50-year age group. The data were compared with those of a community-based cohort in Korea. RESULTS: Eighty-four HIV-positive male patients were included in this study. Median age was 49 (interquartile range [IQR], 45–56) years, and median body mass index (BMI) was 22.6 (IQR, 20.9–24.4). Viral suppression was achieved in 75 (89.3%) patients and median duration of antiretroviral therapy was 71 (IQR, 36–120) months. The overall prevalence of low bone mass was 16.7% in the 40–49 years age group and 54.8% in the>50 years age group. Our cohort had significantly lower bone mass at the femur neck and total hip than HIV-negative Koreans in the 40–49 years age group. Low bone mass was significantly associated with low BMI, and a high level of serum carboxy-terminal collagen crosslinks, but was not associated with antiretroviral regimen or duration of antiretroviral therapy. CONCLUSIONS: Low bone mass is prevalent in Korean HIV-positive males undergoing antiretroviral therapy, and may be associated with increased bone resorption. International AIDS Society 2014-01-09 /pmc/articles/PMC3888902/ /pubmed/24433984 http://dx.doi.org/10.7448/IAS.17.1.18773 Text en © 2014 Choe PG et al; licensee International AIDS Society http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Choe, Pyoeng Gyun
Choi, Hyung Jin
Kim, Nak-Hyun
Park, Wan Beom
Song, Kyoung-Ho
Bang, Ji Hwan
Kim, Eu Suk
Park, Sang Won
Kim, Hong Bin
Oh, Myoung-don
Kim, Nam Joong
High prevalence of low bone mass and associated factors in Korean HIV-positive male patients undergoing antiretroviral therapy
title High prevalence of low bone mass and associated factors in Korean HIV-positive male patients undergoing antiretroviral therapy
title_full High prevalence of low bone mass and associated factors in Korean HIV-positive male patients undergoing antiretroviral therapy
title_fullStr High prevalence of low bone mass and associated factors in Korean HIV-positive male patients undergoing antiretroviral therapy
title_full_unstemmed High prevalence of low bone mass and associated factors in Korean HIV-positive male patients undergoing antiretroviral therapy
title_short High prevalence of low bone mass and associated factors in Korean HIV-positive male patients undergoing antiretroviral therapy
title_sort high prevalence of low bone mass and associated factors in korean hiv-positive male patients undergoing antiretroviral therapy
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888902/
https://www.ncbi.nlm.nih.gov/pubmed/24433984
http://dx.doi.org/10.7448/IAS.17.1.18773
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