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Role of estrogen in angiogenesis in cardiovascular diseases

The formation of new blood vessels from existing ones is a major process of angiogenesis and it is most effective in the vascular systems. The physiological process like hypoxia inducible factors involved in the regeneration of damaged tissues varies within the vascular systems in the endothelium an...

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Detalles Bibliográficos
Autores principales: Barnabas, Oche, Wang, Hong, Gao, Xiu-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888921/
https://www.ncbi.nlm.nih.gov/pubmed/24454332
http://dx.doi.org/10.3969/j.issn.1671-5411.2013.04.008
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author Barnabas, Oche
Wang, Hong
Gao, Xiu-Mei
author_facet Barnabas, Oche
Wang, Hong
Gao, Xiu-Mei
author_sort Barnabas, Oche
collection PubMed
description The formation of new blood vessels from existing ones is a major process of angiogenesis and it is most effective in the vascular systems. The physiological process like hypoxia inducible factors involved in the regeneration of damaged tissues varies within the vascular systems in the endothelium and could be limited due to some major angiogenic growth factors like vascular endothelial growth factor, fibroblast growth factors and epidermal growth factor among others which bring about this cellular vascular regrowth. These physiological processes leading to cellular vascular regrowth could be a major function for the treatment of cardiovascular diseases such as ischemia and atherosclerosis. Estrogens are one of the known factors within the cellular mechanisms that could initiate repairs to the damaged vascular tissues, since estrogens are known inducers of angiogenesis leading to this cellular regrowth. Research has also shown that this cellular regrowth is induced by vascular angiogenic growth factors via the estrogen receptors. In this review we will attempt to summarize the main angiogenic growth factors involved in these physiological processes leading to angiogenesis and possible new mechanisms that could lead to this vascular regrowth. And also we will try to summarize some reports on the effect of estrogen on these physiological processes leading to angiogenesis in cardiovascular diseases.
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spelling pubmed-38889212014-01-21 Role of estrogen in angiogenesis in cardiovascular diseases Barnabas, Oche Wang, Hong Gao, Xiu-Mei J Geriatr Cardiol Review The formation of new blood vessels from existing ones is a major process of angiogenesis and it is most effective in the vascular systems. The physiological process like hypoxia inducible factors involved in the regeneration of damaged tissues varies within the vascular systems in the endothelium and could be limited due to some major angiogenic growth factors like vascular endothelial growth factor, fibroblast growth factors and epidermal growth factor among others which bring about this cellular vascular regrowth. These physiological processes leading to cellular vascular regrowth could be a major function for the treatment of cardiovascular diseases such as ischemia and atherosclerosis. Estrogens are one of the known factors within the cellular mechanisms that could initiate repairs to the damaged vascular tissues, since estrogens are known inducers of angiogenesis leading to this cellular regrowth. Research has also shown that this cellular regrowth is induced by vascular angiogenic growth factors via the estrogen receptors. In this review we will attempt to summarize the main angiogenic growth factors involved in these physiological processes leading to angiogenesis and possible new mechanisms that could lead to this vascular regrowth. And also we will try to summarize some reports on the effect of estrogen on these physiological processes leading to angiogenesis in cardiovascular diseases. Science Press 2013-12 /pmc/articles/PMC3888921/ /pubmed/24454332 http://dx.doi.org/10.3969/j.issn.1671-5411.2013.04.008 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Review
Barnabas, Oche
Wang, Hong
Gao, Xiu-Mei
Role of estrogen in angiogenesis in cardiovascular diseases
title Role of estrogen in angiogenesis in cardiovascular diseases
title_full Role of estrogen in angiogenesis in cardiovascular diseases
title_fullStr Role of estrogen in angiogenesis in cardiovascular diseases
title_full_unstemmed Role of estrogen in angiogenesis in cardiovascular diseases
title_short Role of estrogen in angiogenesis in cardiovascular diseases
title_sort role of estrogen in angiogenesis in cardiovascular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888921/
https://www.ncbi.nlm.nih.gov/pubmed/24454332
http://dx.doi.org/10.3969/j.issn.1671-5411.2013.04.008
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