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Role of estrogen in angiogenesis in cardiovascular diseases
The formation of new blood vessels from existing ones is a major process of angiogenesis and it is most effective in the vascular systems. The physiological process like hypoxia inducible factors involved in the regeneration of damaged tissues varies within the vascular systems in the endothelium an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Science Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888921/ https://www.ncbi.nlm.nih.gov/pubmed/24454332 http://dx.doi.org/10.3969/j.issn.1671-5411.2013.04.008 |
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author | Barnabas, Oche Wang, Hong Gao, Xiu-Mei |
author_facet | Barnabas, Oche Wang, Hong Gao, Xiu-Mei |
author_sort | Barnabas, Oche |
collection | PubMed |
description | The formation of new blood vessels from existing ones is a major process of angiogenesis and it is most effective in the vascular systems. The physiological process like hypoxia inducible factors involved in the regeneration of damaged tissues varies within the vascular systems in the endothelium and could be limited due to some major angiogenic growth factors like vascular endothelial growth factor, fibroblast growth factors and epidermal growth factor among others which bring about this cellular vascular regrowth. These physiological processes leading to cellular vascular regrowth could be a major function for the treatment of cardiovascular diseases such as ischemia and atherosclerosis. Estrogens are one of the known factors within the cellular mechanisms that could initiate repairs to the damaged vascular tissues, since estrogens are known inducers of angiogenesis leading to this cellular regrowth. Research has also shown that this cellular regrowth is induced by vascular angiogenic growth factors via the estrogen receptors. In this review we will attempt to summarize the main angiogenic growth factors involved in these physiological processes leading to angiogenesis and possible new mechanisms that could lead to this vascular regrowth. And also we will try to summarize some reports on the effect of estrogen on these physiological processes leading to angiogenesis in cardiovascular diseases. |
format | Online Article Text |
id | pubmed-3888921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Science Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38889212014-01-21 Role of estrogen in angiogenesis in cardiovascular diseases Barnabas, Oche Wang, Hong Gao, Xiu-Mei J Geriatr Cardiol Review The formation of new blood vessels from existing ones is a major process of angiogenesis and it is most effective in the vascular systems. The physiological process like hypoxia inducible factors involved in the regeneration of damaged tissues varies within the vascular systems in the endothelium and could be limited due to some major angiogenic growth factors like vascular endothelial growth factor, fibroblast growth factors and epidermal growth factor among others which bring about this cellular vascular regrowth. These physiological processes leading to cellular vascular regrowth could be a major function for the treatment of cardiovascular diseases such as ischemia and atherosclerosis. Estrogens are one of the known factors within the cellular mechanisms that could initiate repairs to the damaged vascular tissues, since estrogens are known inducers of angiogenesis leading to this cellular regrowth. Research has also shown that this cellular regrowth is induced by vascular angiogenic growth factors via the estrogen receptors. In this review we will attempt to summarize the main angiogenic growth factors involved in these physiological processes leading to angiogenesis and possible new mechanisms that could lead to this vascular regrowth. And also we will try to summarize some reports on the effect of estrogen on these physiological processes leading to angiogenesis in cardiovascular diseases. Science Press 2013-12 /pmc/articles/PMC3888921/ /pubmed/24454332 http://dx.doi.org/10.3969/j.issn.1671-5411.2013.04.008 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. |
spellingShingle | Review Barnabas, Oche Wang, Hong Gao, Xiu-Mei Role of estrogen in angiogenesis in cardiovascular diseases |
title | Role of estrogen in angiogenesis in cardiovascular diseases |
title_full | Role of estrogen in angiogenesis in cardiovascular diseases |
title_fullStr | Role of estrogen in angiogenesis in cardiovascular diseases |
title_full_unstemmed | Role of estrogen in angiogenesis in cardiovascular diseases |
title_short | Role of estrogen in angiogenesis in cardiovascular diseases |
title_sort | role of estrogen in angiogenesis in cardiovascular diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888921/ https://www.ncbi.nlm.nih.gov/pubmed/24454332 http://dx.doi.org/10.3969/j.issn.1671-5411.2013.04.008 |
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