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Effect of Subthalamic Stimulation on Voice and Speech in Parkinson’s Disease: For the Better or Worse?
Background: Deep brain stimulation of the subthalamic nucleus, although highly effective for the treatment of motor impairment in Parkinson’s disease (PD), can induce speech deterioration in a subgroup of patients. The aim of the current study was to survey (1) if there are distinctive stimulation e...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888994/ https://www.ncbi.nlm.nih.gov/pubmed/24454305 http://dx.doi.org/10.3389/fneur.2013.00218 |
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author | Skodda, Sabine Grönheit, Wenke Schlegel, Uwe Südmeyer, Martin Schnitzler, Alfons Wojtecki, Lars |
author_facet | Skodda, Sabine Grönheit, Wenke Schlegel, Uwe Südmeyer, Martin Schnitzler, Alfons Wojtecki, Lars |
author_sort | Skodda, Sabine |
collection | PubMed |
description | Background: Deep brain stimulation of the subthalamic nucleus, although highly effective for the treatment of motor impairment in Parkinson’s disease (PD), can induce speech deterioration in a subgroup of patients. The aim of the current study was to survey (1) if there are distinctive stimulation effects on the different parameters of voice and speech and (2) if there is a special pattern of preexisting speech abnormalities indicating a risk for further worsening under stimulation. Methods: N = 38 patients with PD had to perform a speech test without medication with stimulation ON (StimON) and stimulation OFF (StimOFF). Speech samples were analyzed: (1) according to a four-dimensional perceptual speech score and (2) by acoustic analysis to obtain quantifiable measures of distinctive speech parameters. Results: Quality of voice was ameliorated with StimON, and there were trends of increased loudness and better pitch variability. N = 8 patients featured a deterioration of speech with StimON, caused by worsening of articulation or/and fluency. These patients already had more severe overall speech impairment with characteristic features of articulatory slurring and articulatory acceleration under StimOFF condition. Conclusion: The influence of subthalamic StimON Parkinsonian speech differs considerably between individual patients, however, there is a trend to amelioration of voice quality and prosody. Patients with stimulation-associated speech deterioration featured higher overall speech impairment and showed a distinctive pattern of articulatory abnormalities at baseline. Further investigations to confirm these preliminary findings are necessary to allow neurologists to pre-surgically estimate the individual risk of deterioration of speech under stimulation. |
format | Online Article Text |
id | pubmed-3888994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38889942014-01-22 Effect of Subthalamic Stimulation on Voice and Speech in Parkinson’s Disease: For the Better or Worse? Skodda, Sabine Grönheit, Wenke Schlegel, Uwe Südmeyer, Martin Schnitzler, Alfons Wojtecki, Lars Front Neurol Neuroscience Background: Deep brain stimulation of the subthalamic nucleus, although highly effective for the treatment of motor impairment in Parkinson’s disease (PD), can induce speech deterioration in a subgroup of patients. The aim of the current study was to survey (1) if there are distinctive stimulation effects on the different parameters of voice and speech and (2) if there is a special pattern of preexisting speech abnormalities indicating a risk for further worsening under stimulation. Methods: N = 38 patients with PD had to perform a speech test without medication with stimulation ON (StimON) and stimulation OFF (StimOFF). Speech samples were analyzed: (1) according to a four-dimensional perceptual speech score and (2) by acoustic analysis to obtain quantifiable measures of distinctive speech parameters. Results: Quality of voice was ameliorated with StimON, and there were trends of increased loudness and better pitch variability. N = 8 patients featured a deterioration of speech with StimON, caused by worsening of articulation or/and fluency. These patients already had more severe overall speech impairment with characteristic features of articulatory slurring and articulatory acceleration under StimOFF condition. Conclusion: The influence of subthalamic StimON Parkinsonian speech differs considerably between individual patients, however, there is a trend to amelioration of voice quality and prosody. Patients with stimulation-associated speech deterioration featured higher overall speech impairment and showed a distinctive pattern of articulatory abnormalities at baseline. Further investigations to confirm these preliminary findings are necessary to allow neurologists to pre-surgically estimate the individual risk of deterioration of speech under stimulation. Frontiers Media S.A. 2014-01-13 /pmc/articles/PMC3888994/ /pubmed/24454305 http://dx.doi.org/10.3389/fneur.2013.00218 Text en Copyright © 2014 Skodda, Grönheit, Schlegel, Südmeyer, Schnitzler and Wojtecki. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Skodda, Sabine Grönheit, Wenke Schlegel, Uwe Südmeyer, Martin Schnitzler, Alfons Wojtecki, Lars Effect of Subthalamic Stimulation on Voice and Speech in Parkinson’s Disease: For the Better or Worse? |
title | Effect of Subthalamic Stimulation on Voice and Speech in Parkinson’s Disease: For the Better or Worse? |
title_full | Effect of Subthalamic Stimulation on Voice and Speech in Parkinson’s Disease: For the Better or Worse? |
title_fullStr | Effect of Subthalamic Stimulation on Voice and Speech in Parkinson’s Disease: For the Better or Worse? |
title_full_unstemmed | Effect of Subthalamic Stimulation on Voice and Speech in Parkinson’s Disease: For the Better or Worse? |
title_short | Effect of Subthalamic Stimulation on Voice and Speech in Parkinson’s Disease: For the Better or Worse? |
title_sort | effect of subthalamic stimulation on voice and speech in parkinson’s disease: for the better or worse? |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888994/ https://www.ncbi.nlm.nih.gov/pubmed/24454305 http://dx.doi.org/10.3389/fneur.2013.00218 |
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