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Prognostic factors for mortality with fungal blood stream infections in patients with hematological and non-hematological malignancies
BACKGROUND: This single center retrospective analysis was undertaken to identify the incidence, clinical impact, and prognostic factors for mortality associated with fungal blood stream infections (BSI) in cancer patients. MATERIALS AND METHODS: One hundred and twenty four patients had 169 episodes...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889042/ https://www.ncbi.nlm.nih.gov/pubmed/24455639 http://dx.doi.org/10.4103/2278-330X.119920 |
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author | Salih, Zena Cavet, Jim Dennis, Mike Somervaille, Tim Bloor, Adrian Kulkarni, Samar |
author_facet | Salih, Zena Cavet, Jim Dennis, Mike Somervaille, Tim Bloor, Adrian Kulkarni, Samar |
author_sort | Salih, Zena |
collection | PubMed |
description | BACKGROUND: This single center retrospective analysis was undertaken to identify the incidence, clinical impact, and prognostic factors for mortality associated with fungal blood stream infections (BSI) in cancer patients. MATERIALS AND METHODS: One hundred and twenty four patients had 169 episodes of fungal BSI. Incidence has not changed over a 10 year period but non albicans candida species are the predominant fungal isolates. Mortality with fungal BSI was significantly higher than that with other microbial agents. Risk of mortality was associated with renal dysfunction and Candida albicans as the isolate. Type of chemotherapy, patient characteristics, and neutrophil count did not influence the mortality following fungal BSI. CONCLUSION: Fungal BSI is rare and the incidence has not changed in this hospital. Mortality associated with fungal BSI is high. Risk score at the time of developing fungal BSI has prognostic potential to identify patients with higher risk of mortality associated with fungal BSI. |
format | Online Article Text |
id | pubmed-3889042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38890422014-01-16 Prognostic factors for mortality with fungal blood stream infections in patients with hematological and non-hematological malignancies Salih, Zena Cavet, Jim Dennis, Mike Somervaille, Tim Bloor, Adrian Kulkarni, Samar South Asian J Cancer THE WAR ON MICROBES: Original Article BACKGROUND: This single center retrospective analysis was undertaken to identify the incidence, clinical impact, and prognostic factors for mortality associated with fungal blood stream infections (BSI) in cancer patients. MATERIALS AND METHODS: One hundred and twenty four patients had 169 episodes of fungal BSI. Incidence has not changed over a 10 year period but non albicans candida species are the predominant fungal isolates. Mortality with fungal BSI was significantly higher than that with other microbial agents. Risk of mortality was associated with renal dysfunction and Candida albicans as the isolate. Type of chemotherapy, patient characteristics, and neutrophil count did not influence the mortality following fungal BSI. CONCLUSION: Fungal BSI is rare and the incidence has not changed in this hospital. Mortality associated with fungal BSI is high. Risk score at the time of developing fungal BSI has prognostic potential to identify patients with higher risk of mortality associated with fungal BSI. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3889042/ /pubmed/24455639 http://dx.doi.org/10.4103/2278-330X.119920 Text en Copyright: © South Asian Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | THE WAR ON MICROBES: Original Article Salih, Zena Cavet, Jim Dennis, Mike Somervaille, Tim Bloor, Adrian Kulkarni, Samar Prognostic factors for mortality with fungal blood stream infections in patients with hematological and non-hematological malignancies |
title | Prognostic factors for mortality with fungal blood stream infections in patients with hematological and non-hematological malignancies |
title_full | Prognostic factors for mortality with fungal blood stream infections in patients with hematological and non-hematological malignancies |
title_fullStr | Prognostic factors for mortality with fungal blood stream infections in patients with hematological and non-hematological malignancies |
title_full_unstemmed | Prognostic factors for mortality with fungal blood stream infections in patients with hematological and non-hematological malignancies |
title_short | Prognostic factors for mortality with fungal blood stream infections in patients with hematological and non-hematological malignancies |
title_sort | prognostic factors for mortality with fungal blood stream infections in patients with hematological and non-hematological malignancies |
topic | THE WAR ON MICROBES: Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889042/ https://www.ncbi.nlm.nih.gov/pubmed/24455639 http://dx.doi.org/10.4103/2278-330X.119920 |
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