Chronic myeloid leukemia in children and adolescents: A single center experience from Eastern India

CONTEXT: Chronic Myeloid Leukemia (CML) constitutes around 3% of leukemia in the children and adolescent age group. AIMS: The aim of the study was to evaluate the characteristics at presentation and the treatment outcome of CML in the children and adolescent age group. SETTINGS AND DESIGN: Retrospective analysis was carried out at a single center in India. MATERIALS AND METHODS: Thirteen patients (≤17 years) attending CML outdoor from April 2008 to August 2012 were included in the analysis. STATISTICAL ANALYSIS USED: The mean and median of various parameters were calculated using a Microsoft excel sheet. SPSS 16.0 version software was used to calculate OS and PFS. RESULTS: CML-CP was the most common phase at presentation. Maximum patients belonged to the 14 - 17 year old age group. Disease was common in the male sex. Splenic discomfort and asthenia were the most common symptoms and splenomegaly was the most common sign. CONCLUSIONS: The treatment with Imatinib was effective and well-tolerated.