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Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase

BACKGROUND: Elucidation of the mechanisms by which gastric cancer cells acquire resistance to 5-fluorouracil (5FU) may provide important clues to the development of effective chemotherapy for 5FU-resistant gastric cancer METHODS: Four 5FU-resistant cell lines (MKN45/5FU, MKN74/5FU, NCI-N87/5FU, and...

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Detalles Bibliográficos
Autores principales:	Nakamura, Ayako, Nakajima, Go, Okuyama, Ryuji, Kuramochi, Hidekazu, Kondoh, Yurin, Kanemura, Toshinori, Takechi, Teiji, Yamamoto, Masakazu, Hayashi, Kazuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Japan 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889291/ https://www.ncbi.nlm.nih.gov/pubmed/23494117 http://dx.doi.org/10.1007/s10120-013-0249-7

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