Isolated Chorea Associated with LGI1 Antibody

BACKGROUND: Leucine-rich glioma inactivated 1 (LGI1) antibody produces a syndrome of limbic encephalitis, hyponatremia, and facio-brachial dystonic seizures that is non-paraneoplastic and responsive to corticosteroids. Parkinsonism, tremor, and generalized chorea are rare manifestations of LGI1, but...

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Detalles Bibliográficos
Autores principales: Ramdhani, Ritesh A., Frucht, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia University Libraries/Information Services 2014
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889335/
https://www.ncbi.nlm.nih.gov/pubmed/24459615
http://dx.doi.org/10.7916/D8MG7MFC
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author Ramdhani, Ritesh A.
Frucht, Steven J.
author_facet Ramdhani, Ritesh A.
Frucht, Steven J.
author_sort Ramdhani, Ritesh A.
collection PubMed
description BACKGROUND: Leucine-rich glioma inactivated 1 (LGI1) antibody produces a syndrome of limbic encephalitis, hyponatremia, and facio-brachial dystonic seizures that is non-paraneoplastic and responsive to corticosteroids. Parkinsonism, tremor, and generalized chorea are rare manifestations of LGI1, but, when present, commonly accompany other signs of limbic encephalitis. CASE REPORT: We present a case of LGI1-related isolated chorea in a 53-year-old Japanese male. His chorea responded to high-dose steroids, suggesting a potential role for this synaptic antibody in triggering chorea. DISCUSSION: This case highlights a new treatable etiology of chorea.
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spelling pubmed-38893352014-01-23 Isolated Chorea Associated with LGI1 Antibody Ramdhani, Ritesh A. Frucht, Steven J. Tremor Other Hyperkinet Mov (N Y) Case Reports BACKGROUND: Leucine-rich glioma inactivated 1 (LGI1) antibody produces a syndrome of limbic encephalitis, hyponatremia, and facio-brachial dystonic seizures that is non-paraneoplastic and responsive to corticosteroids. Parkinsonism, tremor, and generalized chorea are rare manifestations of LGI1, but, when present, commonly accompany other signs of limbic encephalitis. CASE REPORT: We present a case of LGI1-related isolated chorea in a 53-year-old Japanese male. His chorea responded to high-dose steroids, suggesting a potential role for this synaptic antibody in triggering chorea. DISCUSSION: This case highlights a new treatable etiology of chorea. Columbia University Libraries/Information Services 2014-01-08 /pmc/articles/PMC3889335/ /pubmed/24459615 http://dx.doi.org/10.7916/D8MG7MFC Text en http://creativecommons.org/licenses/by-nc-nd/3.0/us/ This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommerical–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.
spellingShingle Case Reports
Ramdhani, Ritesh A.
Frucht, Steven J.
Isolated Chorea Associated with LGI1 Antibody
title Isolated Chorea Associated with LGI1 Antibody
title_full Isolated Chorea Associated with LGI1 Antibody
title_fullStr Isolated Chorea Associated with LGI1 Antibody
title_full_unstemmed Isolated Chorea Associated with LGI1 Antibody
title_short Isolated Chorea Associated with LGI1 Antibody
title_sort isolated chorea associated with lgi1 antibody
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889335/
https://www.ncbi.nlm.nih.gov/pubmed/24459615
http://dx.doi.org/10.7916/D8MG7MFC
work_keys_str_mv AT ramdhaniritesha isolatedchoreaassociatedwithlgi1antibody
AT fruchtstevenj isolatedchoreaassociatedwithlgi1antibody

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