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Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles

Zinc oxide (ZnO) is known to induce lung toxicity, including terminal bronchiolar epithelial hyperplasia, which gives rise to concerns that nanosized ZnO (nZnO) might lead to lung carcinogenesis. We studied the tumor promoting activity of nZnO by an initiation–promotion protocol using human c-Ha-ras...

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Detalles Bibliográficos
Autores principales:	Xu, Jiegou, Futakuchi, Mitsuru, Alexander, David B., Fukamachi, Katsumi, Numano, Takamasa, Suzui, Masumi, Shimizu, Hideo, Omori, Toyonori, Kanno, Jun, Hirose, Akihiko, Tsuda, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2013
Materias:	Inorganic Compounds
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889829/ https://www.ncbi.nlm.nih.gov/pubmed/23832296 http://dx.doi.org/10.1007/s00204-013-1086-5

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