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Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter

Sixty-three Arabic patients (16 males and 47 females) with thyroid toxic and nontoxic goiter who attended the endocrinologist in Nuclear Medicine Hospital and Al Yarmok Nuclear Medicine Department in Baghdad, Iraq were examined for thyroid peroxidase (TPO) gene mutations. A total of ten heterozygous...

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Autores principales: AL-Faisal, A. H. M., AL-Ramahi, I. J., Abudl-Hassan, I. A., Hamdan, A. T., Barusrux, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer London 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890059/
https://www.ncbi.nlm.nih.gov/pubmed/24482635
http://dx.doi.org/10.1007/s00580-012-1572-9
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author AL-Faisal, A. H. M.
AL-Ramahi, I. J.
Abudl-Hassan, I. A.
Hamdan, A. T.
Barusrux, S.
author_facet AL-Faisal, A. H. M.
AL-Ramahi, I. J.
Abudl-Hassan, I. A.
Hamdan, A. T.
Barusrux, S.
author_sort AL-Faisal, A. H. M.
collection PubMed
description Sixty-three Arabic patients (16 males and 47 females) with thyroid toxic and nontoxic goiter who attended the endocrinologist in Nuclear Medicine Hospital and Al Yarmok Nuclear Medicine Department in Baghdad, Iraq were examined for thyroid peroxidase (TPO) gene mutations. A total of ten heterozygous mutations have been identified in the human TPO gene associated with thyroid toxic and nontoxic goiter. These mutations involved transition or transversion of cysteine either by thymine or guanine at the position 1708 of the exon 10 (c.1708C>T) and the position 1978 of the exon 11 (c.1978C>G). From a total of ten detected mutations, two c.1978C>G mutations were detected in nontoxic goiter patients and eight (two c.1708C>T and six c.1978C>G mutations) were detected in toxic goiter. In conclusion, this study identified ten TPO mutations associated with toxic and nontoxic goiter that have not been yet reported in Iraq, and most of them are detected among females (90 %) and adults age between 30 and 50 years old (80 %).
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spelling pubmed-38900592014-01-28 Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter AL-Faisal, A. H. M. AL-Ramahi, I. J. Abudl-Hassan, I. A. Hamdan, A. T. Barusrux, S. Comp Clin Path Original Article Sixty-three Arabic patients (16 males and 47 females) with thyroid toxic and nontoxic goiter who attended the endocrinologist in Nuclear Medicine Hospital and Al Yarmok Nuclear Medicine Department in Baghdad, Iraq were examined for thyroid peroxidase (TPO) gene mutations. A total of ten heterozygous mutations have been identified in the human TPO gene associated with thyroid toxic and nontoxic goiter. These mutations involved transition or transversion of cysteine either by thymine or guanine at the position 1708 of the exon 10 (c.1708C>T) and the position 1978 of the exon 11 (c.1978C>G). From a total of ten detected mutations, two c.1978C>G mutations were detected in nontoxic goiter patients and eight (two c.1708C>T and six c.1978C>G mutations) were detected in toxic goiter. In conclusion, this study identified ten TPO mutations associated with toxic and nontoxic goiter that have not been yet reported in Iraq, and most of them are detected among females (90 %) and adults age between 30 and 50 years old (80 %). Springer London 2012-08-08 2014 /pmc/articles/PMC3890059/ /pubmed/24482635 http://dx.doi.org/10.1007/s00580-012-1572-9 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
AL-Faisal, A. H. M.
AL-Ramahi, I. J.
Abudl-Hassan, I. A.
Hamdan, A. T.
Barusrux, S.
Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter
title Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter
title_full Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter
title_fullStr Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter
title_full_unstemmed Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter
title_short Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter
title_sort detection of heterozygous c.1708c>t and c.1978c>g thyroid peroxidase (tpo) mutations in iraqi patients with toxic and nontoxic goiter
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890059/
https://www.ncbi.nlm.nih.gov/pubmed/24482635
http://dx.doi.org/10.1007/s00580-012-1572-9
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