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Eicosapentaenoic Acid Activates RAS/ERK/C/EBPβ Pathway through H-Ras Intron 1 CpG Island Demethylation in U937 Leukemia Cells

Epigenetic alterations, including aberrant DNA methylation, contribute to tumor development and progression. Silencing of tumor suppressor genes may be ascribed to promoter DNA hypermethylation, a reversible phenomenon intensely investigated as potential therapeutic target. Previously, we demonstrat...

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Detalles Bibliográficos
Autores principales:	Ceccarelli, Veronica, Nocentini, Giuseppe, Billi, Monia, Racanicchi, Serena, Riccardi, Carlo, Roberti, Rita, Grignani, Francesco, Binaglia, Luciano, Vecchini, Alba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890293/ https://www.ncbi.nlm.nih.gov/pubmed/24454781 http://dx.doi.org/10.1371/journal.pone.0085025

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