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XPC promotes MDM2-mediated degradation of the p53 tumor suppressor

Although ubiquitin receptor Rad23 has been implicated in bringing ubiquitylated p53 to the proteasome, how Rad23 recognizes p53 remains unclear. We demonstrate that XPC, a Rad23-binding protein, regulates p53 turnover. p53 protein in XPC-deficient cells remains ubiquitylated, but its association wit...

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Detalles Bibliográficos
Autores principales:	Krzeszinski, Jing Yan, Choe, Vitnary, Shao, Jia, Bao, Xin, Cheng, Haili, Luo, Shiwen, Huo, Keke, Rao, Hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890342/ https://www.ncbi.nlm.nih.gov/pubmed/24258024 http://dx.doi.org/10.1091/mbc.E13-05-0293

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