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Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling

Smoothened (Smo) is a member of the Frizzled (FzD) class of G-protein-coupled-receptors (GPCRs), and functions as the key transducer in the Hedgehog (Hh) signalling pathway. Smo has an extracellular cysteine-rich domain (CRD), indispensable for its function and downstream Hh signalling. Despite its...

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Detalles Bibliográficos
Autores principales:	Rana, Rajashree, Carroll, Candace E., Lee, Ho-Jin, Bao, Ju, Marada, Suresh, Grace, Christy R. R., Guibao, Cristina D., Ogden, Stacey K., Zheng, Jie J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890372/ https://www.ncbi.nlm.nih.gov/pubmed/24351982 http://dx.doi.org/10.1038/ncomms3965

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