Successful use of eculizumab in an 86-year-old patient with paroxysmal nocturnal hemoglobinuria in Japan

Eculizumab was used to treat an 86-year-old male patient with paroxysmal nocturnal hemoglobinuria, the oldest reported case in Japan. As observed in younger patients, this drug rapidly suppressed hemolysis in the present patient, which allowed weaning from blood transfusion. Eculizumab treatment has...

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Detalles Bibliográficos
Autores principales: Ooe, Yokiko, Nagai, Tomoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890435/
https://www.ncbi.nlm.nih.gov/pubmed/24455465
http://dx.doi.org/10.1186/2193-1801-3-10
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author Ooe, Yokiko
Nagai, Tomoko
author_facet Ooe, Yokiko
Nagai, Tomoko
author_sort Ooe, Yokiko
collection PubMed
description Eculizumab was used to treat an 86-year-old male patient with paroxysmal nocturnal hemoglobinuria, the oldest reported case in Japan. As observed in younger patients, this drug rapidly suppressed hemolysis in the present patient, which allowed weaning from blood transfusion. Eculizumab treatment has been continued for 2 years and resulted in the alleviation of renal dysfunction. Despite the patient’s advanced age, the inhibition of complement activity caused by this drug did not result in infection, indicating that it is safe to use in elderly patients.
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spelling pubmed-38904352014-01-22 Successful use of eculizumab in an 86-year-old patient with paroxysmal nocturnal hemoglobinuria in Japan Ooe, Yokiko Nagai, Tomoko Springerplus Case Study Eculizumab was used to treat an 86-year-old male patient with paroxysmal nocturnal hemoglobinuria, the oldest reported case in Japan. As observed in younger patients, this drug rapidly suppressed hemolysis in the present patient, which allowed weaning from blood transfusion. Eculizumab treatment has been continued for 2 years and resulted in the alleviation of renal dysfunction. Despite the patient’s advanced age, the inhibition of complement activity caused by this drug did not result in infection, indicating that it is safe to use in elderly patients. Springer International Publishing 2014-01-04 /pmc/articles/PMC3890435/ /pubmed/24455465 http://dx.doi.org/10.1186/2193-1801-3-10 Text en © Ooe and Nagai; licensee Springer. 2014 This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Study
Ooe, Yokiko
Nagai, Tomoko
Successful use of eculizumab in an 86-year-old patient with paroxysmal nocturnal hemoglobinuria in Japan
title Successful use of eculizumab in an 86-year-old patient with paroxysmal nocturnal hemoglobinuria in Japan
title_full Successful use of eculizumab in an 86-year-old patient with paroxysmal nocturnal hemoglobinuria in Japan
title_fullStr Successful use of eculizumab in an 86-year-old patient with paroxysmal nocturnal hemoglobinuria in Japan
title_full_unstemmed Successful use of eculizumab in an 86-year-old patient with paroxysmal nocturnal hemoglobinuria in Japan
title_short Successful use of eculizumab in an 86-year-old patient with paroxysmal nocturnal hemoglobinuria in Japan
title_sort successful use of eculizumab in an 86-year-old patient with paroxysmal nocturnal hemoglobinuria in japan
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890435/
https://www.ncbi.nlm.nih.gov/pubmed/24455465
http://dx.doi.org/10.1186/2193-1801-3-10
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