Inflammasomes in antiviral immunity: clues for influenza vaccine development

Inflammasomes are cytosolic multiprotein complexes that sense microbial motifs or cellular stress and stimulate caspase-1-dependent cytokine secretion and cell death. Recently, it has become increasingly evident that both DNA and RNA viruses activate inflammasomes, which control innate and adaptive...

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Detalles Bibliográficos
Autores principales: Yamazaki, Tatsuya, Ichinohe, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Vaccine Society 2014
Materias:
Special Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890450/
https://www.ncbi.nlm.nih.gov/pubmed/24427758
http://dx.doi.org/10.7774/cevr.2014.3.1.5
Descripción
Sumario:Inflammasomes are cytosolic multiprotein complexes that sense microbial motifs or cellular stress and stimulate caspase-1-dependent cytokine secretion and cell death. Recently, it has become increasingly evident that both DNA and RNA viruses activate inflammasomes, which control innate and adaptive immune responses against viral infections. In addition, recent studies suggest that certain microbiota induce inflammasomes-dependent adaptive immunity against influenza virus infections. Here, we review recent advances in research into the role of inflammasomes in antiviral immunity.

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