Inflammasomes in antiviral immunity: clues for influenza vaccine development

Inflammasomes are cytosolic multiprotein complexes that sense microbial motifs or cellular stress and stimulate caspase-1-dependent cytokine secretion and cell death. Recently, it has become increasingly evident that both DNA and RNA viruses activate inflammasomes, which control innate and adaptive...

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Detalles Bibliográficos
Autores principales: Yamazaki, Tatsuya, Ichinohe, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Vaccine Society 2014
Materias:
Special Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890450/
https://www.ncbi.nlm.nih.gov/pubmed/24427758
http://dx.doi.org/10.7774/cevr.2014.3.1.5
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author Yamazaki, Tatsuya
Ichinohe, Takeshi
author_facet Yamazaki, Tatsuya
Ichinohe, Takeshi
author_sort Yamazaki, Tatsuya
collection PubMed
description Inflammasomes are cytosolic multiprotein complexes that sense microbial motifs or cellular stress and stimulate caspase-1-dependent cytokine secretion and cell death. Recently, it has become increasingly evident that both DNA and RNA viruses activate inflammasomes, which control innate and adaptive immune responses against viral infections. In addition, recent studies suggest that certain microbiota induce inflammasomes-dependent adaptive immunity against influenza virus infections. Here, we review recent advances in research into the role of inflammasomes in antiviral immunity.
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spelling pubmed-38904502014-01-14 Inflammasomes in antiviral immunity: clues for influenza vaccine development Yamazaki, Tatsuya Ichinohe, Takeshi Clin Exp Vaccine Res Special Article Inflammasomes are cytosolic multiprotein complexes that sense microbial motifs or cellular stress and stimulate caspase-1-dependent cytokine secretion and cell death. Recently, it has become increasingly evident that both DNA and RNA viruses activate inflammasomes, which control innate and adaptive immune responses against viral infections. In addition, recent studies suggest that certain microbiota induce inflammasomes-dependent adaptive immunity against influenza virus infections. Here, we review recent advances in research into the role of inflammasomes in antiviral immunity. The Korean Vaccine Society 2014-01 2013-12-18 /pmc/articles/PMC3890450/ /pubmed/24427758 http://dx.doi.org/10.7774/cevr.2014.3.1.5 Text en © Korean Vaccine Society. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Article
Yamazaki, Tatsuya
Ichinohe, Takeshi
Inflammasomes in antiviral immunity: clues for influenza vaccine development
title Inflammasomes in antiviral immunity: clues for influenza vaccine development
title_full Inflammasomes in antiviral immunity: clues for influenza vaccine development
title_fullStr Inflammasomes in antiviral immunity: clues for influenza vaccine development
title_full_unstemmed Inflammasomes in antiviral immunity: clues for influenza vaccine development
title_short Inflammasomes in antiviral immunity: clues for influenza vaccine development
title_sort inflammasomes in antiviral immunity: clues for influenza vaccine development
topic Special Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890450/
https://www.ncbi.nlm.nih.gov/pubmed/24427758
http://dx.doi.org/10.7774/cevr.2014.3.1.5
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