Complementary studies detecting classical bovine spongiform encephalopathy infectivity in jejunum, ileum and ileocaecal junction in incubating cattle

Recently we have described the distribution of bovine spongiform encephalopathy (BSE) infectivity and/or PrP(Sc) in Peyer’s patches (PP) of the small intestine of orally BSE infected cattle. In this follow-up study additional jejunal and ileal PP’s and ileocaecal-junction tissue samples from 1, 4, a...

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Autores principales: Fast, Christine, Keller, Markus, Balkema-Buschmann, Anne, Hills, Bob, Groschup, Martin H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890602/
https://www.ncbi.nlm.nih.gov/pubmed/24359408
http://dx.doi.org/10.1186/1297-9716-44-123
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author Fast, Christine
Keller, Markus
Balkema-Buschmann, Anne
Hills, Bob
Groschup, Martin H
author_facet Fast, Christine
Keller, Markus
Balkema-Buschmann, Anne
Hills, Bob
Groschup, Martin H
author_sort Fast, Christine
collection PubMed
description Recently we have described the distribution of bovine spongiform encephalopathy (BSE) infectivity and/or PrP(Sc) in Peyer’s patches (PP) of the small intestine of orally BSE infected cattle. In this follow-up study additional jejunal and ileal PP’s and ileocaecal-junction tissue samples from 1, 4, and 24 months post infection (mpi) were examined by mouse (Tgbov XV) bioassay. Infectivity was demonstrated in ileal PP’s 4 mpi and the distribution/extent of infectivity at 24 mpi was comparable to those seen at earlier time points, revealing no indication for a decline/clearance. These data are relevant for the definition of Specified Risk Materials in the context of the TSE legislation worldwide.
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spelling pubmed-38906022014-01-15 Complementary studies detecting classical bovine spongiform encephalopathy infectivity in jejunum, ileum and ileocaecal junction in incubating cattle Fast, Christine Keller, Markus Balkema-Buschmann, Anne Hills, Bob Groschup, Martin H Vet Res Short Report Recently we have described the distribution of bovine spongiform encephalopathy (BSE) infectivity and/or PrP(Sc) in Peyer’s patches (PP) of the small intestine of orally BSE infected cattle. In this follow-up study additional jejunal and ileal PP’s and ileocaecal-junction tissue samples from 1, 4, and 24 months post infection (mpi) were examined by mouse (Tgbov XV) bioassay. Infectivity was demonstrated in ileal PP’s 4 mpi and the distribution/extent of infectivity at 24 mpi was comparable to those seen at earlier time points, revealing no indication for a decline/clearance. These data are relevant for the definition of Specified Risk Materials in the context of the TSE legislation worldwide. BioMed Central 2013 2013-12-21 /pmc/articles/PMC3890602/ /pubmed/24359408 http://dx.doi.org/10.1186/1297-9716-44-123 Text en Copyright © 2013 Fast et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Fast, Christine
Keller, Markus
Balkema-Buschmann, Anne
Hills, Bob
Groschup, Martin H
Complementary studies detecting classical bovine spongiform encephalopathy infectivity in jejunum, ileum and ileocaecal junction in incubating cattle
title Complementary studies detecting classical bovine spongiform encephalopathy infectivity in jejunum, ileum and ileocaecal junction in incubating cattle
title_full Complementary studies detecting classical bovine spongiform encephalopathy infectivity in jejunum, ileum and ileocaecal junction in incubating cattle
title_fullStr Complementary studies detecting classical bovine spongiform encephalopathy infectivity in jejunum, ileum and ileocaecal junction in incubating cattle
title_full_unstemmed Complementary studies detecting classical bovine spongiform encephalopathy infectivity in jejunum, ileum and ileocaecal junction in incubating cattle
title_short Complementary studies detecting classical bovine spongiform encephalopathy infectivity in jejunum, ileum and ileocaecal junction in incubating cattle
title_sort complementary studies detecting classical bovine spongiform encephalopathy infectivity in jejunum, ileum and ileocaecal junction in incubating cattle
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890602/
https://www.ncbi.nlm.nih.gov/pubmed/24359408
http://dx.doi.org/10.1186/1297-9716-44-123
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