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Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme

BACKGROUND: Resistance of the highly aggressive glioblastoma multiforme (GBM) to drug therapy is a major clinical problem resulting in a poor patient’s prognosis. Beside promoter methylation of the O( 6 )-methylguanine-DNA-methyltransferase (MGMT) gene the efflux transporters ABCB1 and ABCG2 have be...

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Detalles Bibliográficos
Autores principales:	Oberstadt, Moritz C, Bien-Möller, Sandra, Weitmann, Kerstin, Herzog, Susann, Hentschel, Katharina, Rimmbach, Christian, Vogelgesang, Silke, Balz, Ellen, Fink, Matthias, Michael, Heike, Zeden, Jan-Philip, Bruckmüller, Henrike, Werk, Anneke N, Cascorbi, Ingolf, Hoffmann, Wolfgang, Rosskopf, Dieter, Schroeder, Henry WS, Kroemer, Heyo K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890604/ https://www.ncbi.nlm.nih.gov/pubmed/24380367 http://dx.doi.org/10.1186/1471-2407-13-617

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