Cargando…

Attentional bias retraining in cigarette smokers attempting smoking cessation (ARTS): Study protocol for a double blind randomised controlled trial

BACKGROUND: Smokers attend preferentially to cigarettes and other smoking-related cues in the environment, in what is known as an attentional bias. There is evidence that attentional bias may contribute to craving and failure to stop smoking. Attentional retraining procedures have been used in labor...

Descripción completa

Detalles Bibliográficos
Autores principales: Begh, Rachna, Munafò, Marcus R, Shiffman, Saul, Ferguson, Stuart G, Nichols, Linda, Mohammed, Mohammed A, Holder, Roger L, Sutton, Stephen, Aveyard, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890623/
https://www.ncbi.nlm.nih.gov/pubmed/24330656
http://dx.doi.org/10.1186/1471-2458-13-1176
_version_ 1782299289596198912
author Begh, Rachna
Munafò, Marcus R
Shiffman, Saul
Ferguson, Stuart G
Nichols, Linda
Mohammed, Mohammed A
Holder, Roger L
Sutton, Stephen
Aveyard, Paul
author_facet Begh, Rachna
Munafò, Marcus R
Shiffman, Saul
Ferguson, Stuart G
Nichols, Linda
Mohammed, Mohammed A
Holder, Roger L
Sutton, Stephen
Aveyard, Paul
author_sort Begh, Rachna
collection PubMed
description BACKGROUND: Smokers attend preferentially to cigarettes and other smoking-related cues in the environment, in what is known as an attentional bias. There is evidence that attentional bias may contribute to craving and failure to stop smoking. Attentional retraining procedures have been used in laboratory studies to train smokers to reduce attentional bias, although these procedures have not been applied in smoking cessation programmes. This trial will examine the efficacy of multiple sessions of attentional retraining on attentional bias, craving, and abstinence in smokers attempting cessation. METHODS/DESIGN: This is a double-blind randomised controlled trial. Adult smokers attending a 7-session weekly stop smoking clinic will be randomised to either a modified visual probe task with attentional retraining or placebo training. Training will start 1 week prior to quit day and be given weekly for 5 sessions. Both groups will receive 21 mg transdermal nicotine patches for 8–12 weeks and withdrawal-orientated behavioural support for 7 sessions. Primary outcome measures are the change in attentional bias reaction time and urge to smoke on the Mood and Physical Symptoms Scale at 4 weeks post-quit. Secondary outcome measures include differences in withdrawal, time to first lapse and prolonged abstinence at 4 weeks post-quit, which will be biochemically validated at each clinic visit. Follow-up will take place at 8 weeks, 3 months and 6 months post-quit. DISCUSSION: This is the first randomised controlled trial of attentional retraining in smokers attempting cessation. This trial could provide proof of principle for a treatment aimed at a fundamental cause of addiction. TRIAL REGISTRATION: Current Controlled Trials: ISRCTN54375405.
format Online
Article
Text
id pubmed-3890623
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-38906232014-01-15 Attentional bias retraining in cigarette smokers attempting smoking cessation (ARTS): Study protocol for a double blind randomised controlled trial Begh, Rachna Munafò, Marcus R Shiffman, Saul Ferguson, Stuart G Nichols, Linda Mohammed, Mohammed A Holder, Roger L Sutton, Stephen Aveyard, Paul BMC Public Health Study Protocol BACKGROUND: Smokers attend preferentially to cigarettes and other smoking-related cues in the environment, in what is known as an attentional bias. There is evidence that attentional bias may contribute to craving and failure to stop smoking. Attentional retraining procedures have been used in laboratory studies to train smokers to reduce attentional bias, although these procedures have not been applied in smoking cessation programmes. This trial will examine the efficacy of multiple sessions of attentional retraining on attentional bias, craving, and abstinence in smokers attempting cessation. METHODS/DESIGN: This is a double-blind randomised controlled trial. Adult smokers attending a 7-session weekly stop smoking clinic will be randomised to either a modified visual probe task with attentional retraining or placebo training. Training will start 1 week prior to quit day and be given weekly for 5 sessions. Both groups will receive 21 mg transdermal nicotine patches for 8–12 weeks and withdrawal-orientated behavioural support for 7 sessions. Primary outcome measures are the change in attentional bias reaction time and urge to smoke on the Mood and Physical Symptoms Scale at 4 weeks post-quit. Secondary outcome measures include differences in withdrawal, time to first lapse and prolonged abstinence at 4 weeks post-quit, which will be biochemically validated at each clinic visit. Follow-up will take place at 8 weeks, 3 months and 6 months post-quit. DISCUSSION: This is the first randomised controlled trial of attentional retraining in smokers attempting cessation. This trial could provide proof of principle for a treatment aimed at a fundamental cause of addiction. TRIAL REGISTRATION: Current Controlled Trials: ISRCTN54375405. BioMed Central 2013-12-13 /pmc/articles/PMC3890623/ /pubmed/24330656 http://dx.doi.org/10.1186/1471-2458-13-1176 Text en Copyright © 2013 Begh et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Study Protocol
Begh, Rachna
Munafò, Marcus R
Shiffman, Saul
Ferguson, Stuart G
Nichols, Linda
Mohammed, Mohammed A
Holder, Roger L
Sutton, Stephen
Aveyard, Paul
Attentional bias retraining in cigarette smokers attempting smoking cessation (ARTS): Study protocol for a double blind randomised controlled trial
title Attentional bias retraining in cigarette smokers attempting smoking cessation (ARTS): Study protocol for a double blind randomised controlled trial
title_full Attentional bias retraining in cigarette smokers attempting smoking cessation (ARTS): Study protocol for a double blind randomised controlled trial
title_fullStr Attentional bias retraining in cigarette smokers attempting smoking cessation (ARTS): Study protocol for a double blind randomised controlled trial
title_full_unstemmed Attentional bias retraining in cigarette smokers attempting smoking cessation (ARTS): Study protocol for a double blind randomised controlled trial
title_short Attentional bias retraining in cigarette smokers attempting smoking cessation (ARTS): Study protocol for a double blind randomised controlled trial
title_sort attentional bias retraining in cigarette smokers attempting smoking cessation (arts): study protocol for a double blind randomised controlled trial
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890623/
https://www.ncbi.nlm.nih.gov/pubmed/24330656
http://dx.doi.org/10.1186/1471-2458-13-1176
work_keys_str_mv AT beghrachna attentionalbiasretrainingincigarettesmokersattemptingsmokingcessationartsstudyprotocolforadoubleblindrandomisedcontrolledtrial
AT munafomarcusr attentionalbiasretrainingincigarettesmokersattemptingsmokingcessationartsstudyprotocolforadoubleblindrandomisedcontrolledtrial
AT shiffmansaul attentionalbiasretrainingincigarettesmokersattemptingsmokingcessationartsstudyprotocolforadoubleblindrandomisedcontrolledtrial
AT fergusonstuartg attentionalbiasretrainingincigarettesmokersattemptingsmokingcessationartsstudyprotocolforadoubleblindrandomisedcontrolledtrial
AT nicholslinda attentionalbiasretrainingincigarettesmokersattemptingsmokingcessationartsstudyprotocolforadoubleblindrandomisedcontrolledtrial
AT mohammedmohammeda attentionalbiasretrainingincigarettesmokersattemptingsmokingcessationartsstudyprotocolforadoubleblindrandomisedcontrolledtrial
AT holderrogerl attentionalbiasretrainingincigarettesmokersattemptingsmokingcessationartsstudyprotocolforadoubleblindrandomisedcontrolledtrial
AT suttonstephen attentionalbiasretrainingincigarettesmokersattemptingsmokingcessationartsstudyprotocolforadoubleblindrandomisedcontrolledtrial
AT aveyardpaul attentionalbiasretrainingincigarettesmokersattemptingsmokingcessationartsstudyprotocolforadoubleblindrandomisedcontrolledtrial