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Efficacy of Irbesartan on Left Ventricular Mass and Arterial Stiffness in Hypertensive Patients
BACKGROUND: Increased aortic stiffness measured by pulse wave velocity (PWV) and left ventricular hypertrophy (LVH) are independent risk factors of cardiovascular events in hypertensive patients. We have conducted a prospective study to examine the effects of the angiotensin II receptor antagonist (...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Internal Medicine
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890731/ https://www.ncbi.nlm.nih.gov/pubmed/16913439 http://dx.doi.org/10.3904/kjim.2006.21.2.103 |
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author | Park, Chang Gyu Ahn, Jeong Cheon Hong, Soon Jun Kim, Eung Joo Lee, Seung Jin Park, Sung Mi Seo, Hong Seog Oh, Dong Joo |
author_facet | Park, Chang Gyu Ahn, Jeong Cheon Hong, Soon Jun Kim, Eung Joo Lee, Seung Jin Park, Sung Mi Seo, Hong Seog Oh, Dong Joo |
author_sort | Park, Chang Gyu |
collection | PubMed |
description | BACKGROUND: Increased aortic stiffness measured by pulse wave velocity (PWV) and left ventricular hypertrophy (LVH) are independent risk factors of cardiovascular events in hypertensive patients. We have conducted a prospective study to examine the effects of the angiotensin II receptor antagonist (irbesartan) on PWV and LVH in hypertensive patients. METHODS: A total of 52 untreated hypertensive patients (age:53.3±8.0 yrs) were enrolled; they had no evidence of associated cardiovascular complications. Blood pressure, heart rate, aortic PWV and left ventricular mass index (LVMI) by 2-D echocardiography were measured at baseline and after irbesartan treatment (150 mg or 300 mg/day) at 12 weeks and 24 weeks. RESULTS: Blood pressure was significantly decreased after 12 weeks and 24 weeks of treatment compared to baseline (SBP: 134.6±13.3 mmHg, 134.0±11.0 mmHg vs 163.7±13.8 mmHg (p)<0.001, DBP: 86.0±10 mmHg, 83.07 mmHg vs 102.4±9.6 mmHg p<0.001, respectively) without significant change in heart rate. LVMI decreased at 12 weeks and at 24 weeks after treatment compared to baseline (from 145.5±35.1 g/m(2) at baseline to 137.5±35.4 g/m(2) at 12 weeks, p=0.017 and 135.3±35.4 g/m(2) at 24 weeks, (p)=0.008). Aortic PWV was decreased after irbesartan treatment at 12 weeks (from 9.6±2.8 m/sec to 8.7±3.1 m/sec at 12 weeks, p=0.064) and at 24 weeks (from 9.6±2.9 m/sec to 7.7±2.1 m/sec at 24 weeks, p=0.007). CONCLUSIONS: Long-term treatment with irbesartan may reduce arterial stiffness and regression of LVH in hypertensive patients. The pleiotropic effects of irbesartan, further decreasing PWV without change of BP between 12 and 24 weeks of treatment, may have favorable vascular effects on arterial stiffness and LVH. |
format | Online Article Text |
id | pubmed-3890731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-38907312014-01-15 Efficacy of Irbesartan on Left Ventricular Mass and Arterial Stiffness in Hypertensive Patients Park, Chang Gyu Ahn, Jeong Cheon Hong, Soon Jun Kim, Eung Joo Lee, Seung Jin Park, Sung Mi Seo, Hong Seog Oh, Dong Joo Korean J Intern Med Original Article BACKGROUND: Increased aortic stiffness measured by pulse wave velocity (PWV) and left ventricular hypertrophy (LVH) are independent risk factors of cardiovascular events in hypertensive patients. We have conducted a prospective study to examine the effects of the angiotensin II receptor antagonist (irbesartan) on PWV and LVH in hypertensive patients. METHODS: A total of 52 untreated hypertensive patients (age:53.3±8.0 yrs) were enrolled; they had no evidence of associated cardiovascular complications. Blood pressure, heart rate, aortic PWV and left ventricular mass index (LVMI) by 2-D echocardiography were measured at baseline and after irbesartan treatment (150 mg or 300 mg/day) at 12 weeks and 24 weeks. RESULTS: Blood pressure was significantly decreased after 12 weeks and 24 weeks of treatment compared to baseline (SBP: 134.6±13.3 mmHg, 134.0±11.0 mmHg vs 163.7±13.8 mmHg (p)<0.001, DBP: 86.0±10 mmHg, 83.07 mmHg vs 102.4±9.6 mmHg p<0.001, respectively) without significant change in heart rate. LVMI decreased at 12 weeks and at 24 weeks after treatment compared to baseline (from 145.5±35.1 g/m(2) at baseline to 137.5±35.4 g/m(2) at 12 weeks, p=0.017 and 135.3±35.4 g/m(2) at 24 weeks, (p)=0.008). Aortic PWV was decreased after irbesartan treatment at 12 weeks (from 9.6±2.8 m/sec to 8.7±3.1 m/sec at 12 weeks, p=0.064) and at 24 weeks (from 9.6±2.9 m/sec to 7.7±2.1 m/sec at 24 weeks, p=0.007). CONCLUSIONS: Long-term treatment with irbesartan may reduce arterial stiffness and regression of LVH in hypertensive patients. The pleiotropic effects of irbesartan, further decreasing PWV without change of BP between 12 and 24 weeks of treatment, may have favorable vascular effects on arterial stiffness and LVH. The Korean Association of Internal Medicine 2006-06 2006-06-30 /pmc/articles/PMC3890731/ /pubmed/16913439 http://dx.doi.org/10.3904/kjim.2006.21.2.103 Text en Copyright © 2006 The Korean Association of Internal Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Chang Gyu Ahn, Jeong Cheon Hong, Soon Jun Kim, Eung Joo Lee, Seung Jin Park, Sung Mi Seo, Hong Seog Oh, Dong Joo Efficacy of Irbesartan on Left Ventricular Mass and Arterial Stiffness in Hypertensive Patients |
title | Efficacy of Irbesartan on Left Ventricular Mass and Arterial Stiffness in Hypertensive Patients |
title_full | Efficacy of Irbesartan on Left Ventricular Mass and Arterial Stiffness in Hypertensive Patients |
title_fullStr | Efficacy of Irbesartan on Left Ventricular Mass and Arterial Stiffness in Hypertensive Patients |
title_full_unstemmed | Efficacy of Irbesartan on Left Ventricular Mass and Arterial Stiffness in Hypertensive Patients |
title_short | Efficacy of Irbesartan on Left Ventricular Mass and Arterial Stiffness in Hypertensive Patients |
title_sort | efficacy of irbesartan on left ventricular mass and arterial stiffness in hypertensive patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890731/ https://www.ncbi.nlm.nih.gov/pubmed/16913439 http://dx.doi.org/10.3904/kjim.2006.21.2.103 |
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