The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages

Integrins play a critical role in the regulation of adhesion, migration, proliferation, and differentiation of cells. Because of the variety of the functions they play in the cell, they are necessary for the formation and maintenance of tissue structure integrity. The trove of data accumulated by re...

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Autores principales: Rippa, A.L., Vorotelyak, E.A., Vasiliev, A.V., Terskikh, V.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890986/
https://www.ncbi.nlm.nih.gov/pubmed/24455180
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author Rippa, A.L.
Vorotelyak, E.A.
Vasiliev, A.V.
Terskikh, V.V.
author_facet Rippa, A.L.
Vorotelyak, E.A.
Vasiliev, A.V.
Terskikh, V.V.
author_sort Rippa, A.L.
collection PubMed
description Integrins play a critical role in the regulation of adhesion, migration, proliferation, and differentiation of cells. Because of the variety of the functions they play in the cell, they are necessary for the formation and maintenance of tissue structure integrity. The trove of data accumulated by researchers suggests that integrins participate in the morphogenesis of the epidermis and its appendages. The development of mice with tissue-specific integrin genes knockout and determination of the genetic basis for a number of skin diseases in humans showed the significance of integrins in the biology, physiology, and morphogenesis of the epidermis and hair follicles. This review discusses the data on the role of different classes of integrin receptors in the biology of epidermal cells, as well as the development of the epidermis and hair follicles.
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spelling pubmed-38909862014-01-16 The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages Rippa, A.L. Vorotelyak, E.A. Vasiliev, A.V. Terskikh, V.V. Acta Naturae Research Article Integrins play a critical role in the regulation of adhesion, migration, proliferation, and differentiation of cells. Because of the variety of the functions they play in the cell, they are necessary for the formation and maintenance of tissue structure integrity. The trove of data accumulated by researchers suggests that integrins participate in the morphogenesis of the epidermis and its appendages. The development of mice with tissue-specific integrin genes knockout and determination of the genetic basis for a number of skin diseases in humans showed the significance of integrins in the biology, physiology, and morphogenesis of the epidermis and hair follicles. This review discusses the data on the role of different classes of integrin receptors in the biology of epidermal cells, as well as the development of the epidermis and hair follicles. A.I. Gordeyev 2013 /pmc/articles/PMC3890986/ /pubmed/24455180 Text en Copyright ® 2013 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rippa, A.L.
Vorotelyak, E.A.
Vasiliev, A.V.
Terskikh, V.V.
The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages
title The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages
title_full The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages
title_fullStr The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages
title_full_unstemmed The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages
title_short The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages
title_sort role of integrins in the development and homeostasis of the epidermis and skin appendages
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890986/
https://www.ncbi.nlm.nih.gov/pubmed/24455180
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