Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin

The effect of epifamin on free radical processes, the activity of caspase-1 and -3, aconitate hydratase and citrate content in rat’s liver at experimentally induced type 2 diabetes mellitus (T2DM) was studied. The action of epifamin at T2DM leads to a decrease in biochemiluminescence parameters, cha...

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Autores principales: Popova, T.N., Agarkov, A.A., Verevkin, A.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890997/
https://www.ncbi.nlm.nih.gov/pubmed/24455191
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author Popova, T.N.
Agarkov, A.A.
Verevkin, A.N.
author_facet Popova, T.N.
Agarkov, A.A.
Verevkin, A.N.
author_sort Popova, T.N.
collection PubMed
description The effect of epifamin on free radical processes, the activity of caspase-1 and -3, aconitate hydratase and citrate content in rat’s liver at experimentally induced type 2 diabetes mellitus (T2DM) was studied. The action of epifamin at T2DM leads to a decrease in biochemiluminescence parameters, characterizing the intensity of free radical processes, and changes in aconitase activity and citrate level towards the control. Activities of caspase-1 and caspase-3 in the tissue decreased by a factor of 2.4 and 1.6 in comparison with the levels at the disease. Apparently, epifamin-mediated correction of the level of melatonin, providing a significant antioxidant effect, promotes positive action on the free radical homeostasis.
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spelling pubmed-38909972014-01-16 Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin Popova, T.N. Agarkov, A.A. Verevkin, A.N. Acta Naturae Research Article The effect of epifamin on free radical processes, the activity of caspase-1 and -3, aconitate hydratase and citrate content in rat’s liver at experimentally induced type 2 diabetes mellitus (T2DM) was studied. The action of epifamin at T2DM leads to a decrease in biochemiluminescence parameters, characterizing the intensity of free radical processes, and changes in aconitase activity and citrate level towards the control. Activities of caspase-1 and caspase-3 in the tissue decreased by a factor of 2.4 and 1.6 in comparison with the levels at the disease. Apparently, epifamin-mediated correction of the level of melatonin, providing a significant antioxidant effect, promotes positive action on the free radical homeostasis. A.I. Gordeyev 2013 /pmc/articles/PMC3890997/ /pubmed/24455191 Text en Copyright ® 2013 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Popova, T.N.
Agarkov, A.A.
Verevkin, A.N.
Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin
title Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin
title_full Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin
title_fullStr Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin
title_full_unstemmed Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin
title_short Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin
title_sort intensity of free radical processes in rat liver under type 2 diabetes and introduction of epifamin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890997/
https://www.ncbi.nlm.nih.gov/pubmed/24455191
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