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The Effects of Methylene Blue on Hemodynamic Parameters and Cytokine Levels in Refractory Septic Shock

BACKGROUND/AIMS: Endogenous nitric oxide (NO) induces the peripheral vasodilation via the activation of guanylate cyclase in patients with septic shock. The purpose of this study was to assess the acute effects of methylene blue (MB), which is an inhibitor of guanylate cyclase, on the hemodynamics a...

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Autores principales: Park, Byung-Kyu, Shim, Tae-Sun, Lim, Chae-Man, Lee, Sang-Do, Kim, Woo-Sung, Kim, Dong-Soon, Kim, Won-Dong, Koh, Younsuck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891380/
https://www.ncbi.nlm.nih.gov/pubmed/16134766
http://dx.doi.org/10.3904/kjim.2005.20.2.123
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author Park, Byung-Kyu
Shim, Tae-Sun
Lim, Chae-Man
Lee, Sang-Do
Kim, Woo-Sung
Kim, Dong-Soon
Kim, Won-Dong
Koh, Younsuck
author_facet Park, Byung-Kyu
Shim, Tae-Sun
Lim, Chae-Man
Lee, Sang-Do
Kim, Woo-Sung
Kim, Dong-Soon
Kim, Won-Dong
Koh, Younsuck
author_sort Park, Byung-Kyu
collection PubMed
description BACKGROUND/AIMS: Endogenous nitric oxide (NO) induces the peripheral vasodilation via the activation of guanylate cyclase in patients with septic shock. The purpose of this study was to assess the acute effects of methylene blue (MB), which is an inhibitor of guanylate cyclase, on the hemodynamics and on the production of pro-inflammatory cytokines and nitric oxide (NO) in patients with refractory septic shock. METHODS: Twenty consecutive patients with refractory septic shock, which was defined as shock refractory to a dopamine infusion of more than 20 µg/kg/min with the appropriate use of antibiotics and adequate volume replacement, received MB infusion of 1 mg/kg intravenously. The hemodynamic and respiratory variables were measured at baseline, 30, 60 and 120 min after an infusion of MB (1 mg/kg). The blood levels of NO, IL-1, IL-10 and TNF-α were measured at baseline, 30 and 120 min after MB infusion. RESULTS: The administration of MB induced an increase in the systemic vascular resistance (SVR) that resulted in an increase of the mean arterial pressure (MAP) in patients with refractory septic shock, and this was without a decrease in cardiac output. The administered MB induced an increase in pulmonary vascular resistance (PVR) that resulted in an increase of pulmonary arterial pressure (PAP), without any deterioration of gas exchange. However, the increases in SVR and PVR were not associated with the alteration of endogenous production of NO, IL-1, IL-10 and TNF-α. CONCLUSION: MB transiently elevated the MAP by increasing the SVR without altering the endogenous productions of NO, IL-1, IL-10 and TNF-α during the study period in patients with refractory septic shock.
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spelling pubmed-38913802014-01-16 The Effects of Methylene Blue on Hemodynamic Parameters and Cytokine Levels in Refractory Septic Shock Park, Byung-Kyu Shim, Tae-Sun Lim, Chae-Man Lee, Sang-Do Kim, Woo-Sung Kim, Dong-Soon Kim, Won-Dong Koh, Younsuck Korean J Intern Med Original Article BACKGROUND/AIMS: Endogenous nitric oxide (NO) induces the peripheral vasodilation via the activation of guanylate cyclase in patients with septic shock. The purpose of this study was to assess the acute effects of methylene blue (MB), which is an inhibitor of guanylate cyclase, on the hemodynamics and on the production of pro-inflammatory cytokines and nitric oxide (NO) in patients with refractory septic shock. METHODS: Twenty consecutive patients with refractory septic shock, which was defined as shock refractory to a dopamine infusion of more than 20 µg/kg/min with the appropriate use of antibiotics and adequate volume replacement, received MB infusion of 1 mg/kg intravenously. The hemodynamic and respiratory variables were measured at baseline, 30, 60 and 120 min after an infusion of MB (1 mg/kg). The blood levels of NO, IL-1, IL-10 and TNF-α were measured at baseline, 30 and 120 min after MB infusion. RESULTS: The administration of MB induced an increase in the systemic vascular resistance (SVR) that resulted in an increase of the mean arterial pressure (MAP) in patients with refractory septic shock, and this was without a decrease in cardiac output. The administered MB induced an increase in pulmonary vascular resistance (PVR) that resulted in an increase of pulmonary arterial pressure (PAP), without any deterioration of gas exchange. However, the increases in SVR and PVR were not associated with the alteration of endogenous production of NO, IL-1, IL-10 and TNF-α. CONCLUSION: MB transiently elevated the MAP by increasing the SVR without altering the endogenous productions of NO, IL-1, IL-10 and TNF-α during the study period in patients with refractory septic shock. The Korean Association of Internal Medicine 2005-06 2005-06-30 /pmc/articles/PMC3891380/ /pubmed/16134766 http://dx.doi.org/10.3904/kjim.2005.20.2.123 Text en Copyright © 2005 The Korean Association of Internal Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Byung-Kyu
Shim, Tae-Sun
Lim, Chae-Man
Lee, Sang-Do
Kim, Woo-Sung
Kim, Dong-Soon
Kim, Won-Dong
Koh, Younsuck
The Effects of Methylene Blue on Hemodynamic Parameters and Cytokine Levels in Refractory Septic Shock
title The Effects of Methylene Blue on Hemodynamic Parameters and Cytokine Levels in Refractory Septic Shock
title_full The Effects of Methylene Blue on Hemodynamic Parameters and Cytokine Levels in Refractory Septic Shock
title_fullStr The Effects of Methylene Blue on Hemodynamic Parameters and Cytokine Levels in Refractory Septic Shock
title_full_unstemmed The Effects of Methylene Blue on Hemodynamic Parameters and Cytokine Levels in Refractory Septic Shock
title_short The Effects of Methylene Blue on Hemodynamic Parameters and Cytokine Levels in Refractory Septic Shock
title_sort effects of methylene blue on hemodynamic parameters and cytokine levels in refractory septic shock
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891380/
https://www.ncbi.nlm.nih.gov/pubmed/16134766
http://dx.doi.org/10.3904/kjim.2005.20.2.123
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