Cargando…
ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro
The ε4 allele of the gene that encodes apolipoprotein E (APOE4) is the greatest genetic risk factor for Alzheimer's disease (AD), while APOE2 reduces AD risk, compared to APOE3. The mechanism(s) underlying the effects of APOE on AD pathology remains unclear. In vivo, dendritic spine density is...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Neurochemistry
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891498/ https://www.ncbi.nlm.nih.gov/pubmed/24328732 http://dx.doi.org/10.1042/AN20130043 |