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ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro

The ε4 allele of the gene that encodes apolipoprotein E (APOE4) is the greatest genetic risk factor for Alzheimer's disease (AD), while APOE2 reduces AD risk, compared to APOE3. The mechanism(s) underlying the effects of APOE on AD pathology remains unclear. In vivo, dendritic spine density is...

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Detalles Bibliográficos
Autores principales: Nwabuisi-Heath, Evelyn, Rebeck, G. William, LaDu, Mary Jo, Yu, Chunjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Neurochemistry 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891498/
https://www.ncbi.nlm.nih.gov/pubmed/24328732
http://dx.doi.org/10.1042/AN20130043

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