Cargando…
JAK2-STAT5 signaling: A novel mechanism of resistance to targeted PI3K/mTOR inhibition
A recent article published by Britschgi et al. in Cancer Cell, “JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer,” describes a positive feedback loop of JAK2/STAT5 activation that drives resistance to PI3K/mTOR...
Autores principales: | Yeh, Jennifer E, Toniolo, Patricia A, Frank, David A |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891630/ https://www.ncbi.nlm.nih.gov/pubmed/24470973 http://dx.doi.org/10.4161/jkst.24635 |
Ejemplares similares
-
Thymoquinone Inhibits JAK/STAT and PI3K/Akt/ mTOR Signaling Pathways in MV4-11 and K562 Myeloid Leukemia Cells
por: Al-Rawashde, Futoon Abedrabbu, et al.
Publicado: (2022) -
PI3K/AKT/mTOR pathway in tumor progression of oligodendrogliomas
por: Lisi, Lucia
Publicado: (2020) -
Targeting PI3K/mTOR Signaling in Cancer
por: Arcaro, Alexandre
Publicado: (2014) -
Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats
por: Hou, Yongying, et al.
Publicado: (2018) -
Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling
por: Oppermann, Henry, et al.
Publicado: (2019)