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JAK2-STAT5 signaling: A novel mechanism of resistance to targeted PI3K/mTOR inhibition

A recent article published by Britschgi et al. in Cancer Cell, “JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer,” describes a positive feedback loop of JAK2/STAT5 activation that drives resistance to PI3K/mTOR...

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Detalles Bibliográficos
Autores principales: Yeh, Jennifer E, Toniolo, Patricia A, Frank, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891630/
https://www.ncbi.nlm.nih.gov/pubmed/24470973
http://dx.doi.org/10.4161/jkst.24635

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