In Vitro and In Vivo Evaluation of Cysteine and Site Specific Conjugated Herceptin Antibody-Drug Conjugates

Antibody drug conjugates (ADCs) are monoclonal antibodies designed to deliver a cytotoxic drug selectively to antigen expressing cells. Several components of an ADC including the selection of the antibody, the linker, the cytotoxic drug payload and the site of attachment used to attach the drug to t...

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Detalles Bibliográficos
Autores principales: Jackson, Dowdy, Atkinson, John, Guevara, Claudia I., Zhang, Chunying, Kery, Vladimir, Moon, Sung-Ju, Virata, Cyrus, Yang, Peng, Lowe, Christine, Pinkstaff, Jason, Cho, Ho, Knudsen, Nick, Manibusan, Anthony, Tian, Feng, Sun, Ying, Lu, Yingchun, Sellers, Aaron, Jia, Xiao-Chi, Joseph, Ingrid, Anand, Banmeet, Morrison, Kendall, Pereira, Daniel S., Stover, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891645/
https://www.ncbi.nlm.nih.gov/pubmed/24454709
http://dx.doi.org/10.1371/journal.pone.0083865

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