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Trafficking regulation of proteins in Alzheimer’s disease

The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer’s disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic throu...

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Detalles Bibliográficos
Autores principales:	Jiang, Shangtong, Li, Yanfang, Zhang, Xian, Bu, Guojun, Xu, Huaxi, Zhang, Yun-wu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891995/ https://www.ncbi.nlm.nih.gov/pubmed/24410826 http://dx.doi.org/10.1186/1750-1326-9-6

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