Overexpression of PTEN suppresses lipopolysaccharide-induced lung fibroblast proliferation, differentiation and collagen secretion through inhibition of the PI3-K-Akt-GSK3beta pathway

BACKGROUND: Abnormal and uncontrolled proliferation of lung fibroblasts may contribute to pulmonary fibrosis. Lipopolysaccharide (LPS) can induce fibroblast proliferation and differentiation through activation of phosphoinositide3-Kinase (PI3-K) pathway. However, the detail mechanism by which LPS co...

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Detalles Bibliográficos
Autores principales: He, Zhengyu, Deng, Yuxiao, Li, Wen, Chen, Yongming, Xing, Shunpeng, Zhao, Xianyuan, Ding, Jia, Gao, Yuan, Wang, Xiangrui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892003/
https://www.ncbi.nlm.nih.gov/pubmed/24387036
http://dx.doi.org/10.1186/2045-3701-4-2

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