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Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer
This study evaluated the efficacy of percutaneous radiofrequency ablation (RFA) for the treatment of metachronous liver metastases of gastric cancer. We enrolled a total of 44 patients who underwent percutaneous RFA for the treatment of metachronous liver metastases after resection of a primary gast...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892106/ https://www.ncbi.nlm.nih.gov/pubmed/23975154 http://dx.doi.org/10.1007/s10585-013-9606-5 |
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author | Hwang, Jun-Eul Kim, Seung-Hun Jin, Joon Hong, Ji-Yun Kim, Min-Jee Jung, Sung-Hoon Shim, Hyun-Jeong Bae, Woo-kyun Hwang, Eu-Chang Kim, Jin-Woong Shin, Sang-Soo Jeong, Oh Park, Young Kyu Cho, Sang-Hee Chung, Ik-Joo |
author_facet | Hwang, Jun-Eul Kim, Seung-Hun Jin, Joon Hong, Ji-Yun Kim, Min-Jee Jung, Sung-Hoon Shim, Hyun-Jeong Bae, Woo-kyun Hwang, Eu-Chang Kim, Jin-Woong Shin, Sang-Soo Jeong, Oh Park, Young Kyu Cho, Sang-Hee Chung, Ik-Joo |
author_sort | Hwang, Jun-Eul |
collection | PubMed |
description | This study evaluated the efficacy of percutaneous radiofrequency ablation (RFA) for the treatment of metachronous liver metastases of gastric cancer. We enrolled a total of 44 patients who underwent percutaneous RFA for the treatment of metachronous liver metastases after resection of a primary gastric adenocarcinoma from January 2002 to November 2011. The primary endpoint of this study was overall survival (OS) and recurrence-free survival (RFS) after RFA. Systemic chemotherapy was combined with RFA in 40 patients; the OS and RFS of the patients with liver-only metastasis who underwent RFA and chemotherapy were 20.9 months (95 % CI 18.4–23.4) and 9.8 months (95 % CI 9.2–10.5), respectively. On multivariate analysis, the factors independently, negatively associated with OS were extrahepatic metastatic lesions (HR 12.6, 95 % CI 3.7–42.9; p = 0.001), no chemotherapy (HR 43.3, 95 % CI 7.4–251.3; p = 0.001), and tumor number ≥2 (HR 2.6, 95 % CI 1.2–5.9; p = 0.015). The factors independently, negatively associated with RFS were extrahepatic metastatic lesions (HR 3.6, 95 % CI 1.6–7.8; p = 0.003) and bilobar intrahepatic distribution (HR 3.9, 95 % CI 1.5–9.9; p = 0.001). The efficacy of percutaneous RFA for metachronous liver metastases of gastric cancer is limited to patients with a single, unilobar metastasis without extrahepatic metastatic lesions. Combined systemic chemotherapy is very important for the prolongation of OS. |
format | Online Article Text |
id | pubmed-3892106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-38921062014-01-21 Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer Hwang, Jun-Eul Kim, Seung-Hun Jin, Joon Hong, Ji-Yun Kim, Min-Jee Jung, Sung-Hoon Shim, Hyun-Jeong Bae, Woo-kyun Hwang, Eu-Chang Kim, Jin-Woong Shin, Sang-Soo Jeong, Oh Park, Young Kyu Cho, Sang-Hee Chung, Ik-Joo Clin Exp Metastasis Research Paper This study evaluated the efficacy of percutaneous radiofrequency ablation (RFA) for the treatment of metachronous liver metastases of gastric cancer. We enrolled a total of 44 patients who underwent percutaneous RFA for the treatment of metachronous liver metastases after resection of a primary gastric adenocarcinoma from January 2002 to November 2011. The primary endpoint of this study was overall survival (OS) and recurrence-free survival (RFS) after RFA. Systemic chemotherapy was combined with RFA in 40 patients; the OS and RFS of the patients with liver-only metastasis who underwent RFA and chemotherapy were 20.9 months (95 % CI 18.4–23.4) and 9.8 months (95 % CI 9.2–10.5), respectively. On multivariate analysis, the factors independently, negatively associated with OS were extrahepatic metastatic lesions (HR 12.6, 95 % CI 3.7–42.9; p = 0.001), no chemotherapy (HR 43.3, 95 % CI 7.4–251.3; p = 0.001), and tumor number ≥2 (HR 2.6, 95 % CI 1.2–5.9; p = 0.015). The factors independently, negatively associated with RFS were extrahepatic metastatic lesions (HR 3.6, 95 % CI 1.6–7.8; p = 0.003) and bilobar intrahepatic distribution (HR 3.9, 95 % CI 1.5–9.9; p = 0.001). The efficacy of percutaneous RFA for metachronous liver metastases of gastric cancer is limited to patients with a single, unilobar metastasis without extrahepatic metastatic lesions. Combined systemic chemotherapy is very important for the prolongation of OS. Springer Netherlands 2013-08-22 2014 /pmc/articles/PMC3892106/ /pubmed/23975154 http://dx.doi.org/10.1007/s10585-013-9606-5 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Research Paper Hwang, Jun-Eul Kim, Seung-Hun Jin, Joon Hong, Ji-Yun Kim, Min-Jee Jung, Sung-Hoon Shim, Hyun-Jeong Bae, Woo-kyun Hwang, Eu-Chang Kim, Jin-Woong Shin, Sang-Soo Jeong, Oh Park, Young Kyu Cho, Sang-Hee Chung, Ik-Joo Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer |
title | Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer |
title_full | Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer |
title_fullStr | Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer |
title_full_unstemmed | Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer |
title_short | Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer |
title_sort | combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892106/ https://www.ncbi.nlm.nih.gov/pubmed/23975154 http://dx.doi.org/10.1007/s10585-013-9606-5 |
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