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BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1

The bromodomain and extra terminal (BET) family protein bromodomain containing protein 4 (BRD4) is an epigenetic regulator recently identified as a therapeutic target for several hematological cancers, notably mixed lineage leukemia-fusion acute myeloid leukemia (MLL-AML). Here, we show that the BRD...

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Detalles Bibliográficos
Autores principales:	Stewart, Helen Jayne Susan, Horne, Gillian Abigail, Bastow, Sarah, Chevassut, Timothy James Telfer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892387/ https://www.ncbi.nlm.nih.gov/pubmed/24403256 http://dx.doi.org/10.1002/cam4.146

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