Cargando…
Occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case–control study conducted in the greater Boston area
Head and neck cancers account for an estimated 549,000 global cancer diagnoses each year. While tobacco use, alcohol consumption, and HPV16 infection are considered to be the major risk factors for this disease, occupational risk factors, including exposure to asbestos, have also been described, alt...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892403/ https://www.ncbi.nlm.nih.gov/pubmed/24403272 http://dx.doi.org/10.1002/cam4.155 |
_version_ | 1782299522235367424 |
---|---|
author | Langevin, Scott M McClean, Michael D Michaud, Dominique S Eliot, Melissa Nelson, Heather H Kelsey, Karl T |
author_facet | Langevin, Scott M McClean, Michael D Michaud, Dominique S Eliot, Melissa Nelson, Heather H Kelsey, Karl T |
author_sort | Langevin, Scott M |
collection | PubMed |
description | Head and neck cancers account for an estimated 549,000 global cancer diagnoses each year. While tobacco use, alcohol consumption, and HPV16 infection are considered to be the major risk factors for this disease, occupational risk factors, including exposure to asbestos, have also been described, although dust exposures other than asbestos have been historically understudied. We have investigated the relationship between occupational exposures to five types of dusts, including sawdust, concrete dust, leather dust, metal dust, and chimney soot, and head and neck squamous cell carcinomas (HNSCC) in the greater Boston area. We report findings from a population-based case–control study involving 951 incident HNSCC cases and 1193 controls, frequency matched on age (±3 years), sex, and town/neighborhood of residence. Multivariable logistic regression was used to assess the association between occupational exposure to each type of dust and HNSCC, overall and by primary tumor site. After adjusting for age, sex, race, smoking, alcohol consumption, education, and HPV16 serology, laryngeal carcinoma risk increased for each decade of occupational exposure to sawdust (OR = 1.2, 95% CI: 1.0, 1.3) and metal dust (OR = 1.2, 95% CI: 1.0, 1.4); and HNSCC risk increased for each decade of occupational leather dust exposure (OR = 1.5, 95% CI: 1.2, 1.9). We have provided evidence for an association between occupational sawdust and metal dust and laryngeal squamous cell carcinoma, and leather dust and HNSCC, with increasing risk with longer duration at the exposed occupation. |
format | Online Article Text |
id | pubmed-3892403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38924032014-01-22 Occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case–control study conducted in the greater Boston area Langevin, Scott M McClean, Michael D Michaud, Dominique S Eliot, Melissa Nelson, Heather H Kelsey, Karl T Cancer Med Cancer Prevention Head and neck cancers account for an estimated 549,000 global cancer diagnoses each year. While tobacco use, alcohol consumption, and HPV16 infection are considered to be the major risk factors for this disease, occupational risk factors, including exposure to asbestos, have also been described, although dust exposures other than asbestos have been historically understudied. We have investigated the relationship between occupational exposures to five types of dusts, including sawdust, concrete dust, leather dust, metal dust, and chimney soot, and head and neck squamous cell carcinomas (HNSCC) in the greater Boston area. We report findings from a population-based case–control study involving 951 incident HNSCC cases and 1193 controls, frequency matched on age (±3 years), sex, and town/neighborhood of residence. Multivariable logistic regression was used to assess the association between occupational exposure to each type of dust and HNSCC, overall and by primary tumor site. After adjusting for age, sex, race, smoking, alcohol consumption, education, and HPV16 serology, laryngeal carcinoma risk increased for each decade of occupational exposure to sawdust (OR = 1.2, 95% CI: 1.0, 1.3) and metal dust (OR = 1.2, 95% CI: 1.0, 1.4); and HNSCC risk increased for each decade of occupational leather dust exposure (OR = 1.5, 95% CI: 1.2, 1.9). We have provided evidence for an association between occupational sawdust and metal dust and laryngeal squamous cell carcinoma, and leather dust and HNSCC, with increasing risk with longer duration at the exposed occupation. Blackwell Publishing Ltd 2013-12 2013-11-04 /pmc/articles/PMC3892403/ /pubmed/24403272 http://dx.doi.org/10.1002/cam4.155 Text en © 2013 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Cancer Prevention Langevin, Scott M McClean, Michael D Michaud, Dominique S Eliot, Melissa Nelson, Heather H Kelsey, Karl T Occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case–control study conducted in the greater Boston area |
title | Occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case–control study conducted in the greater Boston area |
title_full | Occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case–control study conducted in the greater Boston area |
title_fullStr | Occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case–control study conducted in the greater Boston area |
title_full_unstemmed | Occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case–control study conducted in the greater Boston area |
title_short | Occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case–control study conducted in the greater Boston area |
title_sort | occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case–control study conducted in the greater boston area |
topic | Cancer Prevention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892403/ https://www.ncbi.nlm.nih.gov/pubmed/24403272 http://dx.doi.org/10.1002/cam4.155 |
work_keys_str_mv | AT langevinscottm occupationaldustexposureandheadandnecksquamouscellcarcinomariskinapopulationbasedcasecontrolstudyconductedinthegreaterbostonarea AT mccleanmichaeld occupationaldustexposureandheadandnecksquamouscellcarcinomariskinapopulationbasedcasecontrolstudyconductedinthegreaterbostonarea AT michauddominiques occupationaldustexposureandheadandnecksquamouscellcarcinomariskinapopulationbasedcasecontrolstudyconductedinthegreaterbostonarea AT eliotmelissa occupationaldustexposureandheadandnecksquamouscellcarcinomariskinapopulationbasedcasecontrolstudyconductedinthegreaterbostonarea AT nelsonheatherh occupationaldustexposureandheadandnecksquamouscellcarcinomariskinapopulationbasedcasecontrolstudyconductedinthegreaterbostonarea AT kelseykarlt occupationaldustexposureandheadandnecksquamouscellcarcinomariskinapopulationbasedcasecontrolstudyconductedinthegreaterbostonarea |