CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

Chimeric antigen receptors (CARs) can mediate redirected lysis of tumour cells in a major histocompatibility complex (MHC)-independent manner, thereby enabling autologous adoptive T cell therapy for a variety of malignant neoplasms. Currently, most CARs incorporate the T cell receptor (TCR) CD3ζ sig...

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Detalles Bibliográficos
Autores principales: Bridgeman, J S, Ladell, K, Sheard, V E, Miners, K, Hawkins, R E, Price, D A, Gilham, D E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892417/
https://www.ncbi.nlm.nih.gov/pubmed/24116999
http://dx.doi.org/10.1111/cei.12216

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