Nanoparticles containing siRNA to silence CD4 and CCR5 reduce expression of these receptors and inhibit HIV-1 infection in human female reproductive tract tissue explants

Human Immunodeficiency Virus-type 1 (HIV-1) binds to CD4 and CCR5 receptors on target cells in the human female reproductive tract. We sought to determine whether reducing levels of messenger RNA (mRNA) transcripts that encode these receptors in female reproductive tract cells could protect mucosal...

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Detalles Bibliográficos
Autores principales: Eszterhas, Susan K., Ilonzo, Nicole O., Crozier, Jennifer E., Celaj, Stela, Howell, Alexandra L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892589/
https://www.ncbi.nlm.nih.gov/pubmed/24470908
http://dx.doi.org/10.4081/idr.2011.e11

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