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Kinetics of HIV-1 in cerebrospinal fluid and plasma in cryptococcal meningitis
In order to determine HIV-1 kinetics in cerebrospinal fluid (CSF) and plasma in patients with cryptococcal meningitis (CM), we undertook a prospective collection of paired CSF/plasma samples from antiretroviral therapy-free HIV-infected patients with CM. Samples were obtained at baseline (S1) and at...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892634/ https://www.ncbi.nlm.nih.gov/pubmed/24470944 http://dx.doi.org/10.4081/idr.2012.e30 |
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author | Cecchini, Diego M. Cañizal, Ana M. Rojas, Haroldo Arechavala, Alicia Negroni, Ricardo Bouzas, María B. Benetucci, Jorge A. |
author_facet | Cecchini, Diego M. Cañizal, Ana M. Rojas, Haroldo Arechavala, Alicia Negroni, Ricardo Bouzas, María B. Benetucci, Jorge A. |
author_sort | Cecchini, Diego M. |
collection | PubMed |
description | In order to determine HIV-1 kinetics in cerebrospinal fluid (CSF) and plasma in patients with cryptococcal meningitis (CM), we undertook a prospective collection of paired CSF/plasma samples from antiretroviral therapy-free HIV-infected patients with CM. Samples were obtained at baseline (S1) and at the second (S2) and third (S3) weeks of antifungal therapy. HIV-1 CSF concentrations were significantly lower in both S2 and S3 with respect to S1. Plasma concentrations remained stable. HIV-1 concentrations were higher in plasma than CSF in all cases. Patients who survived the episode of CM (but not those who died) showed a decrease in CSF viral load, what suggests different viral kinetics of HIV-1 in the CSF according to the clinical course of this opportunistic disease. |
format | Online Article Text |
id | pubmed-3892634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | PAGEPress Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-38926342014-01-27 Kinetics of HIV-1 in cerebrospinal fluid and plasma in cryptococcal meningitis Cecchini, Diego M. Cañizal, Ana M. Rojas, Haroldo Arechavala, Alicia Negroni, Ricardo Bouzas, María B. Benetucci, Jorge A. Infect Dis Rep Brief Report In order to determine HIV-1 kinetics in cerebrospinal fluid (CSF) and plasma in patients with cryptococcal meningitis (CM), we undertook a prospective collection of paired CSF/plasma samples from antiretroviral therapy-free HIV-infected patients with CM. Samples were obtained at baseline (S1) and at the second (S2) and third (S3) weeks of antifungal therapy. HIV-1 CSF concentrations were significantly lower in both S2 and S3 with respect to S1. Plasma concentrations remained stable. HIV-1 concentrations were higher in plasma than CSF in all cases. Patients who survived the episode of CM (but not those who died) showed a decrease in CSF viral load, what suggests different viral kinetics of HIV-1 in the CSF according to the clinical course of this opportunistic disease. PAGEPress Publications 2012-04-24 /pmc/articles/PMC3892634/ /pubmed/24470944 http://dx.doi.org/10.4081/idr.2012.e30 Text en ©Copyright D.M. Cecchini et al., 2012 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy |
spellingShingle | Brief Report Cecchini, Diego M. Cañizal, Ana M. Rojas, Haroldo Arechavala, Alicia Negroni, Ricardo Bouzas, María B. Benetucci, Jorge A. Kinetics of HIV-1 in cerebrospinal fluid and plasma in cryptococcal meningitis |
title | Kinetics of HIV-1 in cerebrospinal fluid and plasma in cryptococcal meningitis |
title_full | Kinetics of HIV-1 in cerebrospinal fluid and plasma in cryptococcal meningitis |
title_fullStr | Kinetics of HIV-1 in cerebrospinal fluid and plasma in cryptococcal meningitis |
title_full_unstemmed | Kinetics of HIV-1 in cerebrospinal fluid and plasma in cryptococcal meningitis |
title_short | Kinetics of HIV-1 in cerebrospinal fluid and plasma in cryptococcal meningitis |
title_sort | kinetics of hiv-1 in cerebrospinal fluid and plasma in cryptococcal meningitis |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892634/ https://www.ncbi.nlm.nih.gov/pubmed/24470944 http://dx.doi.org/10.4081/idr.2012.e30 |
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