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No clinical or biological difference between Chikungunya and Dengue Fever during the 2010 Gabonese outbreak

Chikungunya (CHIKV) and Dengue (DENV) viruses, both arboviruses, have caused multiple outbreaks worldwide. Their clinical features are poorly described in Africa and there is no comparative study, although Chikungunya is considered as a dengue-like disease. We conducted a comparative study of clinic...

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Autores principales: Nkoghe, Dieudonné, Kassa, Roland Fabrice Kassa, Bisvigou, Ulrich, Caron, Mélanie, Grard, Gilda, Leroy, Eric Maurice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892642/
https://www.ncbi.nlm.nih.gov/pubmed/24470935
http://dx.doi.org/10.4081/idr.2012.e5
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author Nkoghe, Dieudonné
Kassa, Roland Fabrice Kassa
Bisvigou, Ulrich
Caron, Mélanie
Grard, Gilda
Leroy, Eric Maurice
author_facet Nkoghe, Dieudonné
Kassa, Roland Fabrice Kassa
Bisvigou, Ulrich
Caron, Mélanie
Grard, Gilda
Leroy, Eric Maurice
author_sort Nkoghe, Dieudonné
collection PubMed
description Chikungunya (CHIKV) and Dengue (DENV) viruses, both arboviruses, have caused multiple outbreaks worldwide. Their clinical features are poorly described in Africa and there is no comparative study, although Chikungunya is considered as a dengue-like disease. We conducted a comparative study of clinical and biological data from CHIKV and DENV positive patients during the 2010 Gabonese outbreak. Patients consulting with general symptoms and having laboratory confirmation for CHIKV or DENV were included. Clinical and biological data were recorded. Statistical analyses were performed using Epi Info. A P value < 0.05 was considered significant. In all, 270 CHIKV+, 53 DENV+ and 20 co-infected patients were included in the study. Headaches, hemorrhage, leukopenia and lymphopenia were significantly (P respectively 0.01, 0.001, 0.02 and 0.001) more frequent in DENV+ patients than in CHIKV+. There was no additive effect of the two viruses.These clinical and hematological disorders are non specific and cannot assist for the differential diagnosis. These diseases are clinically indistinguishable, and need for laboratory confirmation.
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spelling pubmed-38926422014-01-27 No clinical or biological difference between Chikungunya and Dengue Fever during the 2010 Gabonese outbreak Nkoghe, Dieudonné Kassa, Roland Fabrice Kassa Bisvigou, Ulrich Caron, Mélanie Grard, Gilda Leroy, Eric Maurice Infect Dis Rep Article Chikungunya (CHIKV) and Dengue (DENV) viruses, both arboviruses, have caused multiple outbreaks worldwide. Their clinical features are poorly described in Africa and there is no comparative study, although Chikungunya is considered as a dengue-like disease. We conducted a comparative study of clinical and biological data from CHIKV and DENV positive patients during the 2010 Gabonese outbreak. Patients consulting with general symptoms and having laboratory confirmation for CHIKV or DENV were included. Clinical and biological data were recorded. Statistical analyses were performed using Epi Info. A P value < 0.05 was considered significant. In all, 270 CHIKV+, 53 DENV+ and 20 co-infected patients were included in the study. Headaches, hemorrhage, leukopenia and lymphopenia were significantly (P respectively 0.01, 0.001, 0.02 and 0.001) more frequent in DENV+ patients than in CHIKV+. There was no additive effect of the two viruses.These clinical and hematological disorders are non specific and cannot assist for the differential diagnosis. These diseases are clinically indistinguishable, and need for laboratory confirmation. PAGEPress Publications 2012-01-03 /pmc/articles/PMC3892642/ /pubmed/24470935 http://dx.doi.org/10.4081/idr.2012.e5 Text en ©Copyright D. Nkoghe et al., 2012 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy
spellingShingle Article
Nkoghe, Dieudonné
Kassa, Roland Fabrice Kassa
Bisvigou, Ulrich
Caron, Mélanie
Grard, Gilda
Leroy, Eric Maurice
No clinical or biological difference between Chikungunya and Dengue Fever during the 2010 Gabonese outbreak
title No clinical or biological difference between Chikungunya and Dengue Fever during the 2010 Gabonese outbreak
title_full No clinical or biological difference between Chikungunya and Dengue Fever during the 2010 Gabonese outbreak
title_fullStr No clinical or biological difference between Chikungunya and Dengue Fever during the 2010 Gabonese outbreak
title_full_unstemmed No clinical or biological difference between Chikungunya and Dengue Fever during the 2010 Gabonese outbreak
title_short No clinical or biological difference between Chikungunya and Dengue Fever during the 2010 Gabonese outbreak
title_sort no clinical or biological difference between chikungunya and dengue fever during the 2010 gabonese outbreak
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892642/
https://www.ncbi.nlm.nih.gov/pubmed/24470935
http://dx.doi.org/10.4081/idr.2012.e5
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