Cargando…

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

[Image: see text] G-protein coupled receptors (GPCRs) are the primary target class of currently marketed drugs, accounting for about a quarter of all drug targets of approved medicines. However, almost all the screening efforts for novel ligand discovery rely exclusively on cellular systems overexpr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K., Gawron, Sylwia, Sassano, Maria F., Kahsai, Alem W., Wingler, Laura M., Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnard, Jérémy, Read, Kevin D., Roth, Bryan L., Gilbert, Ian H., Hopkins, Andrew L., Lefkowitz, Robert J., Navratilova, Iva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2013
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892729/ https://www.ncbi.nlm.nih.gov/pubmed/24454993 http://dx.doi.org/10.1021/ml400312j

Ejemplares similares

Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor
por: Pani, Biswaranjan, et al.
Publicado: (2021)

Conformation Guides Molecular Efficacy in Docking Screens of Activated β-2 Adrenergic G Protein Coupled Receptor
por: Weiss, Dahlia R., et al.
Publicado: (2013)

Allosteric modulator potentiates β(2)AR agonist–promoted bronchoprotection in asthma models
por: Ahn, Seungkirl, et al.
Publicado: (2023)

Arresting a Transient Receptor Potential (TRP) Channel: β-ARRESTIN 1 MEDIATES UBIQUITINATION AND FUNCTIONAL DOWN-REGULATION OF TRPV4
por: Shukla, Arun K., et al.
Publicado: (2010)

Screening for GPCR Ligands Using Surface Plasmon Resonance
por: Navratilova, Iva, et al.
Publicado: (2011)

Independent β-Arrestin2 and G(q)/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor
por: Kim, Jihee, et al.
Publicado: (2009)

Loss of biased signaling at a G protein-coupled receptor in overexpressed systems
por: Li, Angus, et al.
Publicado: (2023)

β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19
por: Manglik, Aashish, et al.
Publicado: (2020)

Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation
por: Staus, Dean P, et al.
Publicado: (2016)

Conformationally Selective RNA Aptamers Allosterically Modulate the β(2)-Adrenoceptor
por: Kahsai, Alem W., et al.
Publicado: (2016)

The GPCR–β-arrestin complex allosterically activates C-Raf by binding its amino terminus
por: Zang, Yunxiang, et al.
Publicado: (2021)

A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei
por: Urbaniak, Michael D., et al.
Publicado: (2013)

Small-Molecule Positive Allosteric Modulators of the β(2)-Adrenoceptor Isolated from DNA-Encoded Libraries
por: Ahn, Seungkirl, et al.
Publicado: (2018)

Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin
por: Kahsai, Alem W., et al.
Publicado: (2023)

β-Arrestin–dependent activation of Ca(2+)/calmodulin kinase II after β(1)–adrenergic receptor stimulation
por: Mangmool, Supachoke, et al.
Publicado: (2010)

Visualization of arrestin recruitment by a G Protein-Coupled Receptor
por: Shukla, Arun K., et al.
Publicado: (2014)

Role of adrenergic receptors in shock
por: Geevarghese, Mathew, et al.
Publicado: (2023)

Association between Beta Adrenergic Receptor Polymorphism and Ischemic Stroke: A Meta-Analysis
por: Kumar, Amit, et al.
Publicado: (2015)

β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
por: Kim, Jihee, et al.
Publicado: (2018)

Protein-Protein Interactions at the Adrenergic Receptors
por: Cotecchia, Susanna, et al.
Publicado: (2012)

Gi-protein-coupled β (1)-adrenergic receptor: re-understanding the selectivity of β (1)-adrenergic receptor to G protein : Gi-protein-coupled β (1)-adrenergic receptor
por: Chen, Hao, et al.
Publicado: (2022)

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis
por: Schimpl, Marianne, et al.
Publicado: (2012)

Internalization Dissociates β(2)-Adrenergic Receptors
por: Lan, Tien-Hung, et al.
Publicado: (2011)

β-Adrenergic Receptor Signaling in Prostate Cancer
por: Braadland, Peder Rustøen, et al.
Publicado: (2015)

Optodynamic simulation of β-adrenergic receptor signalling
por: Siuda, Edward R., et al.
Publicado: (2015)

β-Adrenergic Receptor and Insulin Resistance in the Heart
por: Mangmool, Supachoke, et al.
Publicado: (2017)

Role of adrenergic receptor signalling in neuroimmune communication
por: Chhatar, Sushanta, et al.
Publicado: (2021)

The Role of Beta-Adrenergic Receptors in Depression and Resilience
por: Zhang, Hongxing, et al.
Publicado: (2022)

Muscle Plasticity and β(2)-Adrenergic Receptors: Adaptive Responses of β(2)-Adrenergic Receptor Expression to Muscle Hypertrophy and Atrophy
por: Sato, Shogo, et al.
Publicado: (2011)

Phosphodiesterase 4D disruption causes β2 adrenergic receptors to behave like β1 adrenergic receptors in vivo
por: Pearl, N, et al.
Publicado: (2006)

Cardiac physiologic regulation of sub-type specific adrenergic receptors in transgenic mice overexpressing β(1)- and β(2)-adrenergic receptors
por: Kim, Ka Eul, et al.
Publicado: (2016)

Characterization of β-adrenergic receptors in bovine intramuscular and subcutaneous adipose tissue: comparison of lubabegron fumarate with β-adrenergic receptor agonists and antagonists
por: Hwang, Jinhee H, et al.
Publicado: (2021)

Homotypic and Heterotypic Adhesion Induced by Odorant Receptors and the β2-Adrenergic Receptor
por: Richard, Marion, et al.
Publicado: (2013)

Influence of Receptor Polymorphisms on the Response to α-Adrenergic Receptor Blockers in Pheochromocytoma Patients
por: Berends, Annika M. A., et al.
Publicado: (2022)

Morphology of astroglial cells is controlled by beta-adrenergic receptors
Publicado: (1987)

Molecular Basis of Ligand Dissociation in β-Adrenergic Receptors
por: González, Angel, et al.
Publicado: (2011)

Effect of cleistanthin A and B on adrenergic and cholinergic receptors
por: Parasuraman, S., et al.
Publicado: (2011)

Agonist-Directed Desensitization of the β(2)-Adrenergic Receptor
por: Goral, Vasiliy, et al.
Publicado: (2011)

Adrenergic receptors and metabolism: role in development of cardiovascular disease
por: Ciccarelli, Michele, et al.
Publicado: (2013)

The Principles of Ligand Specificity on beta-2-adrenergic receptor
por: Chan, H. C. Stephen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_6n82idqt5nmr81rlqb8j8h1lfe